# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4837920 | Binding | Inhibition of wild type HIV1 protease using Arg-Glu (EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg as substrate preincubated for 20 to 30 mins followed by substrate addition and measured for 10 mins by FRET assay | Human immunodeficiency virus 1 | 22 | ALA4837199 | single protein format | Scientific Literature | |
2. | ALA4837921 | Functional | Antiviral activity against HIV1 | Human immunodeficiency virus 1 | 22 | ALA4837199 | organism-based format | Scientific Literature | |
3. | ALA4837922 | ADME | Cytotoxicity against HEK293T cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay | Homo sapiens | 22 | ALA4837199 | cell-based format | Scientific Literature | |
4. | ALA4837923 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against HEK293T cells to IC50 of antiviral activity against HIV1 | 16 | ALA4837199 | cell-based format | Scientific Literature | ||
5. | ALA4837924 | Functional | Antiviral activity against HIV1 Env-deficient VSV-G pseudotyped virus infected in human SUP-T1 cells infected with supernatant of compound treated virus-producing 293T cells assessed as inhibition of late stage viral production at 10 uM treated for 48 hrs with virus-producing 293T cells followed by SUP-T1 cells infection for 48 hrs by single-round infection luciferase assay relative to control | Human immunodeficiency virus 1 | 9 | ALA4837199 | organism-based format | Scientific Literature | |
6. | ALA4837925 | Functional | Antiviral activity against HIV1 (NL4-3) Env-deficient VSV-G pseudotyped virus infected in human SUP-T1 cells assessed as inhibition of early stage viral production at 10 uM measured after 48 hrs by luciferase assay relative to control | Human immunodeficiency virus 1 | 2 | ALA4837199 | organism-based format | Scientific Literature | |
7. | ALA4837927 | Functional | Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as reduction in viral replication by measuring reduction in p24 Gag production by chemiluminescent-EIA | Human immunodeficiency virus 1 | 2 | ALA4837199 | organism-based format | Scientific Literature | |
8. | ALA4837928 | Functional | Antiviral activity against DRV resistant HIV1 infected in human MT4 cells assessed as reduction in viral replication by measuring reduction in p24 Gag production by chemiluminescent-EIA | Human immunodeficiency virus 1 | 2 | ALA4837199 | organism-based format | Scientific Literature | |
9. | ALA4837929 | Functional | Antiviral activity against HIV1 subtype C isolate 11928 | Human immunodeficiency virus 1 | 2 | ALA4837199 | organism-based format | Scientific Literature | |
10. | ALA4837930 | Functional | Antiviral activity against HIV1 subtype C isolate 11929 | Human immunodeficiency virus 1 | 2 | ALA4837199 | organism-based format | Scientific Literature | |
11. | ALA4837931 | Functional | Antiviral activity against HIV1 subtype C isolate 11941 | Human immunodeficiency virus 1 | 2 | ALA4837199 | organism-based format | Scientific Literature | |
12. | ALA4837932 | Functional | Antiviral activity against HIV1 subtype C isolate-plndie | Human immunodeficiency virus 1 | 2 | ALA4837199 | organism-based format | Scientific Literature | |
13. | ALA4837933 | Functional | Resistance index, ratio of IC50 for DRV resistant HIV1 infected in human MT4 cells to IC50 for HIV1 NL4-3 infected in human MT4 cells | 2 | ALA4837199 | cell-based format | Scientific Literature | ||
14. | ALA4837934 | Binding | Potency index, ratio of DRV Ki to test compound Ki for inhibition of wild type HIV1 protease using Arg-Glu (EDANS)-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys(DABCYL)-Arg as substrate preincubated for 20 to 30 mins followed by substrate addition and measured for 10 mins by FRET assay | Human immunodeficiency virus 1 | 1 | ALA4837199 | single protein format | Scientific Literature |