# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4828663 | Binding | Inhibition of tracer 236 binding to recombinant human His-tagged full length CDK8/Cyclin C expressed in baculovirus expression system by Lanthascreen assay | Homo sapiens | 20 | ALA4825780 | assay format | Scientific Literature | |
2. | ALA4828664 | Binding | Inhibition of tracer 236 binding to recombinant human GST/His-tagged CDK11 (1 to 502 residues)/Cyclin C( 1 to 283 residues) expressed in insect cells by Lanthascreen assay | Homo sapiens | 20 | ALA4825780 | cell-based format | Scientific Literature | |
3. | ALA4828665 | Binding | Inhibition of human CDK8 in human Jurkat cells assessed as inhibition of STAT1 phosphorylation at S727 residue measured after 24 hrs by Western blot assay | Homo sapiens | 4 | ALA4825780 | cell-based format | Scientific Literature | |
4. | ALA4828666 | Binding | Inhibition of human wild type partial length STK16 (G11 to I305 residues) expressed in bacterial expression system at 1 uM measured by Kinomescan method | Homo sapiens | 1 | ALA4825780 | assay format | Scientific Literature | |
5. | ALA4828667 | Binding | Inhibition of human partial length FLT3 D385V mutant (V592 to Y969 residues) expressed in mammalian expression system at 1 uM measured by Kinomescan method | Homo sapiens | 1 | ALA4825780 | assay format | Scientific Literature | |
6. | ALA4828668 | Binding | Inhibition of human wild type partial length STK16 (G11 to I305) expressed in bacterial expression system by Kinomescan method | Homo sapiens | 1 | ALA4825780 | assay format | Scientific Literature | |
7. | ALA4828669 | ADME | Metabolic stability in mouse hepatocytes assessed as half life | Mus musculus | 5 | ALA4825780 | cell-based format | Scientific Literature | |
8. | ALA4828670 | ADME | Metabolic stability in mouse hepatocytes assessed as intrinsic clearance | Mus musculus | 5 | ALA4825780 | cell-based format | Scientific Literature | |
9. | ALA4828671 | ADME | Cmax in C57Bl/6 mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4825780 | organism-based format | Scientific Literature | |
10. | ALA4828672 | ADME | AUC in C57Bl/6 mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4825780 | organism-based format | Scientific Literature | |
11. | ALA4828673 | ADME | Half life in C57Bl/6 mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4825780 | organism-based format | Scientific Literature | |
12. | ALA4828674 | ADME | Clearance in C57Bl/6 mouse at 10 mg/kg, po or 2 mg/kg, iv | Mus musculus | 1 | ALA4825780 | organism-based format | Scientific Literature | |
13. | ALA4828675 | ADME | Volume of distribution at steady state in C57Bl/6 mouse at 10 mg/kg, po or 2 mg/kg, iv | Mus musculus | 1 | ALA4825780 | organism-based format | Scientific Literature | |
14. | ALA4828676 | ADME | Oral bioavailability in C57Bl/6 mouse at 10 mg/kg | Mus musculus | 1 | ALA4825780 | organism-based format | Scientific Literature |