# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4818330 | F | Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization by fluorescence based analysis | Homo sapiens | 26 | ALA4814049 | cell-based format | Scientific Literature | |
2. | ALA4818331 | F | Surmountable antagonist activity at human P2Y6 receptor expressed in human1321N1 cells assessed as rightward shift in UDP concentration response curve of inositol-1-phosphate accumulation without affecting maximal effect at 10 uM relative to control | Homo sapiens | 2 | ALA4814049 | cell-based format | Scientific Literature | |
3. | ALA4818344 | F | Antagonist activity at human P2Y6 receptor expressed in human1321N1 cells assessed as rightward shift in UDP concentration response curve of intracellular calcium immobilization with reduced maximal effect at 1 to 9 uM by fluorescence based analysis relative to control | Homo sapiens | 1 | ALA4814049 | cell-based format | Scientific Literature | |
4. | ALA5224965 | B | Antagonist activity at Meleagris P2Y1R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization at 100 uM by FLIPR assay relative to control | Meleagris gallopavo | 5 | ALA5223123 | cell-based format | Scientific Literature | |
5. | ALA5224966 | B | Antagonist activity at human P2Y2R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization at 100 uM by FLIPR assay relative to control | Homo sapiens | 5 | ALA5223123 | cell-based format | Scientific Literature | |
6. | ALA5224967 | B | Antagonist activity at human P2Y4R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization at 100 uM by FLIPR assay relative to control | Homo sapiens | 5 | ALA5223123 | cell-based format | Scientific Literature | |
7. | ALA5224968 | B | Antagonist activity at mouse P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization by FLIPR assay | Mus musculus | 11 | ALA5223123 | cell-based format | Scientific Literature | |
8. | ALA5224970 | B | Selectivity ratio of IC50 for mouse P2Y6R to IC50 for human P2Y6R | 13 | ALA5223123 | assay format | Scientific Literature | ||
9. | ALA5224980 | T | Cytotoxicity against HEK293 cells assessed as reduction in cell viability at 100 uM measured after 24 hrs by MTT assay relative to control | Homo sapiens | 5 | ALA5223123 | cell-based format | Scientific Literature |