| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4825887 | Functional | Antiviral activity against Respiratory syncytial virus A2 infected in African green monkey Vero cells by Plaque reduction assay | Human respiratory syncytial virus | 21 | ALA4825662 | organism-based format | Scientific Literature | |
| 2. | ALA4825888 | ADME | Cytotoxicity against African green monkey Vero cells by MTT assay | Chlorocebus sabaeus | 17 | ALA4825662 | cell-based format | Scientific Literature | |
| 3. | ALA4825891 | ADME | Protein binding in rat plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Rattus norvegicus | 12 | ALA4825662 | cell-free format | Scientific Literature | |
| 4. | ALA4825892 | ADME | Protein binding in dog plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Canis lupus familiaris | 12 | ALA4825662 | cell-free format | Scientific Literature | |
| 5. | ALA4825893 | ADME | Protein binding in human plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Homo sapiens | 12 | ALA4825662 | cell-free format | Scientific Literature | |
| 6. | ALA4825894 | ADME | Intrinsic clearance in Sprague-Dawley rat liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 12 | ALA4825662 | microsome format | Scientific Literature | |
| 7. | ALA4825895 | ADME | Intrinsic clearance in Beagle dog liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Canis lupus familiaris | 12 | ALA4825662 | microsome format | Scientific Literature | |
| 8. | ALA4825896 | ADME | Intrinsic clearance in human liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 12 | ALA4825662 | microsome format | Scientific Literature | |
| 9. | ALA4825906 | Binding | Inhibition of Respiratory syncytial virus A2 fusion protein expressed in HEK293T cells harboring GAL4-NF-kappaB assessed as reduction in cell-cell fusion by luciferase assay | Human respiratory syncytial virus A2 | 24 | ALA4825662 | cell-based format | Scientific Literature | |
| 10. | ALA4825907 | Physicochemical | Thermodynamic solubility in PBS at 1 to 100 uM at pH 7.4 by HPLC-UV method | 11 | ALA4825662 | small-molecule physicochemical format | Scientific Literature | ||
| 11. | ALA4825908 | ADME | Apparent permeability across apical to basolateral side in MDCK-MDR1 cells at 10 uM measured at 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 9 | ALA4825662 | cell-based format | Scientific Literature | |
| 12. | ALA4825909 | ADME | Apparent permeability across basolateral side to apical side in MDCK-MDR1 cells at 10 uM measured at 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 9 | ALA4825662 | cell-based format | Scientific Literature | |
| 13. | ALA4825910 | ADME | Efflux ratio of apparent permeability in MDCK-MDR1 cells at 10 uM measured at 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 9 | ALA4825662 | cell-based format | Scientific Literature | |
| 14. | ALA4825911 | ADME | Intrinsic clearance in rat hepatocytes assessed per million cells at 3 uM measured up to 60 mins by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4825662 | cell-based format | Scientific Literature | |
| 15. | ALA4825912 | ADME | Cmax in Sprague-Dawley rat at 5 mg/kg, po administered via gavage measured after 0.02 to 24 hrs by tandem liquid chromatography/mass spectrometry | Rattus norvegicus | 5 | ALA4825662 | organism-based format | Scientific Literature | |
| 16. | ALA4825913 | ADME | Clearance in Sprague-Dawley rat at 1 mg/kg, iv administered via gavage measured after 0.02 to 24 hrs by tandem liquid chromatography/mass spectrometry | Rattus norvegicus | 5 | ALA4825662 | organism-based format | Scientific Literature | |
| 17. | ALA4825914 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv administered via gavage measured after 0.02 to 24 hrs by tandem liquid chromatography/mass spectrometry | Rattus norvegicus | 5 | ALA4825662 | organism-based format | Scientific Literature | |
| 18. | ALA4825915 | ADME | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg administered via gavage measured after 0.02 to 24 hrs by tandem liquid chromatography/mass spectrometry | Rattus norvegicus | 6 | ALA4825662 | organism-based format | Scientific Literature |
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