| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4823699 | Binding | Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as substrate incubated for 30 mins in presence of ATP by ELISA | Homo sapiens | 32 | ALA4823251 | single protein format | Scientific Literature | |
| 2. | ALA4823700 | Binding | Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity assay | Homo sapiens | 32 | ALA4823251 | cell-based format | Scientific Literature | |
| 3. | ALA4823701 | Binding | Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 mins in presence of ATP at Km concentration by luminescence assay | Homo sapiens | 29 | ALA4823251 | assay format | Scientific Literature | |
| 4. | ALA4823702 | Binding | Selectivity ratio of Ki for full length recombinant GST-tagged VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 mins in presence of ATP at Km concentration by luminescence assay to Ki for full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as substrate incubated for 30 mins in presence of ATP by ELISA | Homo sapiens | 27 | ALA4823251 | assay format | Scientific Literature | |
| 5. | ALA4823703 | Physicochemical | Kinetic solubility of the compound in pH 7.4 PBS buffer incubated for 2 hrs using orbital shaker by LC-UV mass spectrometry | 31 | ALA4823251 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4823704 | ADME | Effective efflux ratio of apparent permeability across basolateral to apical over apical to basolateral side in MDCK-MDR1 cells assessed as efflux ratio after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 9 | ALA4823251 | cell-based format | Scientific Literature | |
| 7. | ALA4823705 | ADME | Apparent permeability across apical to basolateral side in MDCK-MDR1 cells after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 9 | ALA4823251 | cell-based format | Scientific Literature | |
| 8. | ALA4823706 | ADME | Intrinsic clearance in C57Bl/6 mouse pooled liver microsomes at 1 uM measured up to 40 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 9 | ALA4823251 | microsome format | Scientific Literature |
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