| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4843795 | ADME | Inhibition of recombinant human CYP3A4 expressed in Escherichia coli using VG as probe substrate incubated for 15 to 60 mins by fluorometric assay | Homo sapiens | 5 | ALA4842350 | assay format | Scientific Literature | |
| 2. | ALA4843796 | ADME | Time dependent inhibition of recombinant human CYP3A4 expressed in Escherichia coli using 7BQ as probe substrate preincubated for 10 mins followed by NADPH-regenerating system addition and measured at 1 min interval for 30 mins by fluorescence plate reader analysis | Homo sapiens | 1 | ALA4842350 | assay format | Scientific Literature | |
| 3. | ALA4843797 | ADME | Time dependent inhibition of recombinant human CYP3A4 expressed in Escherichia coli using DEF as probe substrate preincubated for 10 mins followed by NADPH-regenerating system addition and measured at 1 min interval for 30 mins by fluorescence plate reader analysis | Homo sapiens | 1 | ALA4842350 | assay format | Scientific Literature | |
| 4. | ALA4843798 | Binding | Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced IL-6 secretion incubated for 18 to 24 hrs by MSD assay | Homo sapiens | 34 | ALA4842350 | tissue-based format | Scientific Literature | |
| 5. | ALA4843799 | Binding | Inhibition of BRD4 in human whole blood assessed as reduction in LPS-induced IL-6 secretion preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by MSD assay | Homo sapiens | 11 | ALA4842350 | tissue-based format | Scientific Literature | |
| 6. | ALA4843801 | ADME | Inhibition of recombinant human CYP2C9 expressed in Escherichia coli using FCA as substrate incubated for 15 to 60 mins by fluorometric assay | Homo sapiens | 6 | ALA4842350 | assay format | Scientific Literature | |
| 7. | ALA4843803 | ADME | Metabolic stability in rat hepatocytes assessed as intrinsic clearance per g liver tissue at 0.5 uM measured upto 120 mins by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4842350 | cell-based format | Scientific Literature | |
| 8. | ALA4843804 | ADME | Metabolic stability in dog hepatocytes assessed as intrinsic clearance per g liver tissue at 0.5 uM measured upto 120 mins by LC-MS/MS analysis | Canis lupus familiaris | 3 | ALA4842350 | cell-based format | Scientific Literature | |
| 9. | ALA4843805 | ADME | Metabolic stability in human hepatocytes assessed as intrinsic clearance per g liver tissue at 0.5 uM measured upto 120 mins by LC-MS/MS analysis | Homo sapiens | 3 | ALA4842350 | cell-based format | Scientific Literature | |
| 10. | ALA4843806 | Binding | Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal 6His-tagged BRD4-BD1 Y390A mutant (1 to 477 residue) expressed in Escherichia coli incubated for 30 mins by TR-FRET assay | Homo sapiens | 33 | ALA4842350 | assay format | Scientific Literature | |
| 11. | ALA4843807 | ADME | Metabolic stability in mouse hepatocytes assessed as intrinsic clearance per g liver tissue at 0.5 uM measured upto 120 mins by LC-MS/MS analysis | Mus musculus | 1 | ALA4842350 | cell-based format | Scientific Literature | |
| 12. | ALA4843808 | ADME | Unbound fraction in Balb/C mouse blood at 100 to 1000 ng/ml by LC-MS/MS-based rapid equilibrium dialysis method | Mus musculus | 1 | ALA4842350 | tissue-based format | Scientific Literature | |
| 13. | ALA4843809 | ADME | Unbound fraction in Wistar Han rat blood at 100 to 1000 ng/ml by LC-MS/MS-based rapid equilibrium dialysis method | Rattus norvegicus | 1 | ALA4842350 | tissue-based format | Scientific Literature | |
| 14. | ALA4843810 | ADME | Unbound fraction in Beagle dog blood at 100 to 1000 ng/ml by LC-MS/MS-based rapid equilibrium dialysis method | Canis lupus familiaris | 1 | ALA4842350 | tissue-based format | Scientific Literature | |
| 15. | ALA4843811 | ADME | Unbound fraction in human blood at 100 to 1000 ng/ml by LC-MS/MS-based rapid equilibrium dialysis method | Homo sapiens | 1 | ALA4842350 | tissue-based format | Scientific Literature | |
| 16. | ALA4843812 | ADME | Inhibition of recombinant human CYP1A2 expressed in Escherichia coli using ER as probe substrate incubated for 15 to 60 mins by fluorometric assay | Homo sapiens | 1 | ALA4842350 | assay format | Scientific Literature | |
| 17. | ALA4843813 | ADME | Inhibition of recombinant human CYP2C19 expressed in Escherichia coli using BMC as probe substrate incubated for 15 to 60 mins by fluorometric assay | Homo sapiens | 1 | ALA4842350 | assay format | Scientific Literature | |
| 18. | ALA4843814 | ADME | Inhibition of recombinant human CYP2D6 expressed in Escherichia coli using MMC as probe substrate incubated for 15 to 60 mins by fluorometric assay | Homo sapiens | 1 | ALA4842350 | assay format | Scientific Literature | |
| 19. | ALA4843815 | ADME | Inhibition of recombinant human CYP3A4 expressed in Escherichia coli using VR as probe substrate incubated for 15 to 60 mins by fluorometric assay | Homo sapiens | 1 | ALA4842350 | assay format | Scientific Literature | |
| 20. | ALA4843816 | ADME | Time dependent inhibition of recombinant human CYP2D6 expressed in Escherichia coli using MMC as probe substrate preincubated for 10 mins followed by NADPH-regenerating system addition and measured at 1 min interval for 30 mins by fluorescence plate reader analysis | Homo sapiens | 1 | ALA4842350 | assay format | Scientific Literature |
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