| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4845048 | B | Inhibition of human recombinant MGAT2 expressed in Sf9 cell membrane using 2-monooleglycerol and [H3]-oleoyl-CoA as substrates incubated for 20 mins by scintillation proximity assay | Homo sapiens | 59 | cell membrane format | Scientific Literature | ||
| 2. | ALA4845049 | B | Inhibition of mouse recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCMS assay | Mus musculus | 59 | cell membrane format | Scientific Literature | ||
| 3. | ALA4845050 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 0.5 uM incubated for 10 mins | Homo sapiens | 49 | microsome format | Scientific Literature | ||
| 4. | ALA4845051 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 0.5 uM incubated for 10 mins | Mus musculus | 49 | microsome format | Scientific Literature | ||
| 5. | ALA4845052 | B | Inhibition of rat recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCMS assay | Rattus norvegicus | 3 | cell membrane format | Scientific Literature | ||
| 6. | ALA4845053 | A | Metabolic stability in rat liver microsomes assessed as compound remaining at 0.5 uM incubated for 10 mins | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
| 7. | ALA4845054 | A | Plasma protein binding in human assessed as unbound fraction | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
| 8. | ALA4845055 | A | Plasma protein binding in rat assessed as unbound fraction | Rattus norvegicus | 3 | cell-free format | Scientific Literature | ||
| 9. | ALA4845056 | A | Plasma protein binding in mouse assessed as unbound fraction | Mus musculus | 3 | cell-free format | Scientific Literature | ||
| 10. | ALA4845057 | P | Aqueous solubility of compound at pH 1 | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA4845058 | P | Aqueous solubility of compound at pH 6.5 | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA4845059 | P | Aqueous solubility of compound at pH 7.4 | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA4845060 | A | Permeability of compound at pH 5.5 by PAMPA assay | 3 | assay format | Scientific Literature | |||
| 14. | ALA4845061 | A | Permeability of compound at pH 7.4 by PAMPA assay | 3 | assay format | Scientific Literature | |||
| 15. | ALA4845062 | A | Cmax in C57BL6 mouse at 30 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA4845063 | A | AUC in C57BL6 mouse at 30 mg/kg, po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA4845064 | A | Oral bioavailability in C57BL6 mouse at 30 mg/kg | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA4845065 | B | Inhibition of human MGAT3 | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 19. | ALA4845066 | B | Inhibition of human AWAT2 | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 20. | ALA4845067 | B | Inhibition of human DGAT1 | Homo sapiens | 3 | single protein format | Scientific Literature |
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