| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4839804 | Binding | Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight by ELISA | Homo sapiens | 34 | ALA4837257 | cell-based format | Scientific Literature | |
| 2. | ALA4839805 | ADME | Unbound clearance in human hepatocytes | Homo sapiens | 25 | ALA4837257 | cell-based format | Scientific Literature | |
| 3. | ALA4839806 | ADME | Ratio of of free drug concentration in mouse brain to EC90 for modulation of gamma secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight by ELISA | 12 | ALA4837257 | cell-based format | Scientific Literature | ||
| 4. | ALA4839807 | Functional | Invivo modulation of gamma secretase in mouse assessed as reduction in Abeta42 levels in brain at 30 mg/kg, po measured after 6 hrs relative to control | Mus musculus | 12 | ALA4837257 | organism-based format | Scientific Literature |
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