# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4813050 | Binding | Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated for 45 hrs by luciferase reporter gene assay | Homo sapiens | 8 | ALA4811278 | cell-based format | Scientific Literature | |
2. | ALA4813051 | Binding | Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated for 45 hrs by luciferase reporter gene assay | Mus musculus | 8 | ALA4811278 | cell-based format | Scientific Literature | |
3. | ALA4813052 | Binding | Agonist activity at Gal4-fused human PPARgamma expressed in monkey CV1 cells assessed as receptor transactivation incubated for 45 hrs by luciferase reporter gene assay | Homo sapiens | 8 | ALA4811278 | cell-based format | Scientific Literature | |
4. | ALA4813053 | Binding | Agonist activity at Gal4-fused human PPARdelta expressed in monkey CV1 cells assessed as receptor transactivation incubated for 45 hrs by luciferase reporter gene assay | Homo sapiens | 8 | ALA4811278 | cell-based format | Scientific Literature | |
5. | ALA4813054 | Functional | Hypolipidemic activity in high fat diet-induced nonalcoholic steatohepatitis C57BL/6J mouse model assessed as reduction in plasma triglyceride level at 3 mg/kg, po administered via gavage and measured after 24 hrs | Mus musculus | 10 | ALA4811278 | organism-based format | Scientific Literature | |
6. | ALA4813056 | Functional | In vivo agonist activity at PPARalpha in high fat diet-induced nonalcoholic steatohepatitis C57BL/6J mouse model assessed as increase in LPL mRNA expression in liver administered at 3 mg/kg, po and measured after 24 hrs by quantitative real time PCR analysis | Mus musculus | 8 | ALA4811278 | organism-based format | Scientific Literature | |
7. | ALA4813057 | Functional | In vivo agonist activity at PPARalpha in high fat diet-induced nonalcoholic steatohepatitis C57BL/6J mouse model assessed as trans-repression of ApoC3 mRNA expression in liver administered at 3 mg/kg, po and measured after 24 hrs by quantitative real time PCR analysis | Mus musculus | 9 | ALA4811278 | organism-based format | Scientific Literature | |
8. | ALA4813058 | Functional | In vivo agonist activity at PPARalpha in high fat diet-induced nonalcoholic steatohepatitis C57BL/6J mouse model assessed as increase in ACOX1 mRNA expression in liver administered at 3 mg/kg, po and measured after 24 hrs by quantitative real time PCR analysis | Mus musculus | 10 | ALA4811278 | organism-based format | Scientific Literature | |
9. | ALA4813059 | Functional | In vivo agonist activity at PPARalpha in high fat diet-induced nonalcoholic steatohepatitis C57BL/6J mouse model assessed as increase in Cyp4a3 mRNA expression in liver administered at 3 mg/kg, po and measured after 24 hrs by quantitative real time PCR analysis | Mus musculus | 10 | ALA4811278 | organism-based format | Scientific Literature | |
10. | ALA4813082 | Functional | Upregulation of PPARalpha expression in liver of high fat diet-induced nonalcoholic steatohepatitis C57BL/6J mouse model at 3 mg/kg, po and measured after 24 hrs by quantitative real time PCR analysis | Mus musculus | 9 | ALA4811278 | organism-based format | Scientific Literature |