# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4812131 | Functional | Antitrypanosomal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC-5 SV2 cells assessed as inhibition of parasite growth measured after 7 days by spectrophotometric analysis | Trypanosoma cruzi | 80 | ALA4811241 | organism-based format | Scientific Literature | |
2. | ALA4812132 | ADME | Cytotoxicity against human MRC-5 SV2 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis | Homo sapiens | 79 | ALA4811241 | cell-based format | Scientific Literature | |
3. | ALA4812133 | Toxicity | Selectivity index, ratio of CC50 for human MRC-5 SV2 cells to IC50 for antitrypanosomal activity against nifurtimox-sensitive Trypanosoma cruzi Tulahuen CL2 infected in human MRC-5 SV2 cells | 55 | ALA4811241 | cell-based format | Scientific Literature | ||
4. | ALA4812134 | Functional | Antileishmanial activity against amastigote form of Leishmania infantum MHOM/MA(BE)/67 infected in Swiss mouse peritoneal macrophages assessed as reduction in parasite growth treated at 2 hrs post-infection and measured after 5 days by Giemsa staining based microscopic analysis | Leishmania infantum | 80 | ALA4811241 | organism-based format | Scientific Literature | |
5. | ALA4812135 | ADME | Cytotoxicity against Swiss mouse peritoneal macrophages assessed as cell detachment, lysis and granulation measured after 5 days by microscopic analysis | Mus musculus | 79 | ALA4811241 | cell-based format | Scientific Literature | |
6. | ALA4812136 | Toxicity | Selectivity index, ratio of CC50 for Swiss mouse peritoneal macrophages to IC50 for antileishmanial activity against amastigote form of Leishmania infantum MHOM/MA(BE)/67 infected in Swiss mouse peritoneal macrophages | 30 | ALA4811241 | assay format | Scientific Literature |