# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4833055 | Binding | Inhibition of recombinant Trypanosoma brucei rhodesiense MVAT4 rhodesain expressed in Pichia pastoris at 100 uM using Z-FR-AMC as substrate by fluorometry relative to control | Trypanosoma brucei rhodesiense | 19 | ALA4831522 | assay format | Scientific Literature | |
2. | ALA4833070 | Functional | Trypanocidal activity against amastigotes form of Trypanosoma cruzi CA-I/72 infected in mouse C2C12 cells assessed as inhibition of parasite replication incubated for 48 hrs by DAPI staining based microscopic analysis | Trypanosoma cruzi | 25 | ALA4831522 | organism-based format | Scientific Literature | |
3. | ALA4833071 | ADME | Cytotoxicity against mouse C2C12 cells | Mus musculus | 25 | ALA4831522 | cell-based format | Scientific Literature | |
4. | ALA4833072 | Toxicity | Selectivity index, ratio of CC50 for cytotoxicity against mouse C2C12 cells to EC50 for trypanocidal activity against Trypanosoma cruzi C-I/72 infected in mouse C2C12 cells | 24 | ALA4831522 | cell-based format | Scientific Literature | ||
5. | ALA4833073 | Functional | Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms measured after 72 hrs by SYBR green dye based assay | Trypanosoma brucei brucei | 25 | ALA4831522 | organism-based format | Scientific Literature |