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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4844381 A Half life in ICR mouse at 3 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 2. ALA4844382 A Tmax in ICR mouse at 5 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 3. ALA4844383 A Half life in ICR mouse at 5 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 4. ALA4844384 B Protac activity at VHL3/AR in human VCaP cells assessed as induction of AR degradation at 0.001 uM measured after 24 hrs by western blot analysis relative to control Homo sapiens 38 cell-based format Scientific Literature 5. ALA4844385 B Protac activity at VHL3/AR in human VCaP cells assessed as induction of AR degradation at 0.01 uM measured after 24 hrs by western blot analysis relative to control Homo sapiens 38 cell-based format Scientific Literature 6. ALA4844386 B Protac activity at VHL3/AR in human VCaP cells assessed as induction of AR degradation at 0.1 uM measured after 24 hrs by western blot analysis relative to control Homo sapiens 38 cell-based format Scientific Literature 7. ALA4844387 B Protac activity at VHL3/AR in human VCAP cells assessed as induction of AR degradation at 1 uM by western blot analysis relative to control Homo sapiens 38 cell-based format Scientific Literature 8. ALA4844391 B Protac activity at VHL/AR in human VCaP cells assessed as induction of AR degradation measured after 24 hrs by western blot analysis Homo sapiens 5 cell-based format Scientific Literature 9. ALA4844392 B Protac activity at VHL/AR T878A mutant in human LNCaP cells assessed as induction of AR degradation measured after 24 hrs by western blot analysis Homo sapiens 5 cell-based format Scientific Literature 10. ALA4844393 B Protac activity at VHL/AR in human VCaP cells assessed as reduction in AR protein level at 100 nM measured after 3 hrs by western blot analysis Homo sapiens 5 cell-based format Scientific Literature 11. ALA4844394 B Protac activity at VHL/AR T878A mutant in human LNCaP cells assessed as reduction in AR protein level at 100 nM measured after 6 hrs by western blot analysis Homo sapiens 5 cell-based format Scientific Literature 12. ALA4844395 F Growth inhibition of human VCaP cells assessed as cell viability measured after 4 days in presence of R1881 by WST-8 assay Homo sapiens 8 cell-based format Scientific Literature 13. ALA4844396 F Growth inhibition of human LNCaP cells assessed as cell viability measured after 4 days in presence of R1881 by WST-8 assay Homo sapiens 8 cell-based format Scientific Literature 14. ALA4844409 A Half life in ICR mouse at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 15. ALA4844410 A Half life in ICR mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 16. ALA4844411 A AUC (0 to t) in ICR mouse at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 17. ALA4844412 A AUC (0 to t) in ICR mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 18. ALA4844413 A Clearance in ICR mouse at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 19. ALA4844414 A Clearance in ICR mouse at 1 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature 20. ALA4844415 A Volume of distribution at steady state in ICR mouse at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis Mus musculus 5 organism-based format Scientific Literature