# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4822017 | Binding | Activation of human NAMPT assessed as increase in NMN production by fluorescence based analysis | Homo sapiens | 19 | ALA4819093 | single protein format | Scientific Literature | |
2. | ALA4822018 | Binding | Activation of human NAMPT assessed as increase in NMN production at 100 uM by fluorescence based analysis relative to 30 uM ethyl 4-(3-(pyridin-4-ylmethyl)ureido)benzoate | Homo sapiens | 19 | ALA4819093 | single protein format | Scientific Literature | |
3. | ALA4822019 | Binding | Activation of NAMPT in human HEK293-A cells assessed as increase in NAD+ level at 1 uM by NAD/NADH-Glo assay relative to 30 uM ethyl 4-(3-(pyridin-4-ylmethyl)ureido)benzoate | Homo sapiens | 19 | ALA4819093 | cell-based format | Scientific Literature | |
4. | ALA4822020 | Binding | Activation of NAMPT in human HEK293-A cells assessed as increase in NAD+ level at 3 uM by NAD/NADH-Glo assay relative to 30 uM ethyl 4-(3-(pyridin-4-ylmethyl)ureido)benzoate | Homo sapiens | 19 | ALA4819093 | cell-based format | Scientific Literature | |
5. | ALA4822021 | Binding | Activation of NAMPT in human HEK293-A cells assessed as increase in NAD+ level at 10 uM by NAD/NADH-Glo assay relative to 30 uM ethyl 4-(3-(pyridin-4-ylmethyl)ureido)benzoate | Homo sapiens | 19 | ALA4819093 | cell-based format | Scientific Literature | |
6. | ALA4822022 | Physicochemical | 1-Octanol/PBS buffer distribution coefficient, log D of the compound at pH 7.4 | 12 | ALA4819093 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4822029 | ADME | Inhibition of CYP1A2 (unknown origin) at 10 uM measured after 10 mins | Homo sapiens | 14 | ALA4819093 | single protein format | Scientific Literature | |
8. | ALA4822030 | ADME | Inhibition of CYP2C9 (unknown origin) at 10 uM measured after 10 mins | Homo sapiens | 14 | ALA4819093 | single protein format | Scientific Literature | |
9. | ALA4822031 | ADME | Inhibition of CYP2D6 (unknown origin) at 10 uM measured after 10 mins | Homo sapiens | 14 | ALA4819093 | single protein format | Scientific Literature | |
10. | ALA4822032 | ADME | Inhibition of CYP3A4 (unknown origin) at 10 uM measured after 10 mins | Homo sapiens | 14 | ALA4819093 | single protein format | Scientific Literature |