# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3829382 | Functional | Attenuation of methicillin-resistant Staphylococcus aureus Mu 50 virulence in BALB/c mouse systemic infection model assessed as decrease in bacterial survival in liver at 200 mg/kg, ip administered every 12 hrs for 108 hrs followed by bacterial challenge after first 12 hrs of compound dosing measured 5 days post infection | Staphylococcus aureus | 2 | ALA3826951 | organism-based format | Scientific Literature | |
2. | ALA3830152 | Functional | Attenuation of methicillin-resistant Staphylococcus aureus USA400 MW2 virulence in BALB/c mouse systemic infection model assessed as decrease in bacterial burden in liver at 200 mg/kg, ip administered every 12 hrs for 108 hrs followed by bacterial challenge after first 12 hrs of compound dosing measured 5 days post infection | Staphylococcus aureus | 2 | ALA3826951 | organism-based format | Scientific Literature | |
3. | ALA3830153 | Functional | Attenuation of methicillin-resistant Staphylococcus aureus USA400 MW2 virulence in BALB/c mouse systemic infection model assessed as decrease in bacterial burden in liver at 50 mg/kg, ip administered every 12 hrs for 108 hrs followed by bacterial challenge after first 12 hrs of compound dosing measured 5 days post infection | Staphylococcus aureus | 2 | ALA3826951 | organism-based format | Scientific Literature | |
4. | ALA3830156 | Functional | Attenuation of methicillin-resistant Staphylococcus aureus Mu 50 virulence in BALB/c mouse systemic infection model assessed as decrease in bacterial survival in liver at 50 mg/kg, ip administered every 12 hrs for 108 hrs followed by bacterial challenge after first 12 hrs of compound dosing measured 5 days post infection | Staphylococcus aureus | 2 | ALA3826951 | organism-based format | Scientific Literature | |
5. | ALA3830157 | Functional | Attenuation of methicillin-resistant Staphylococcus aureus Mu 50 virulence in BALB/c mouse systemic infection model assessed as decrease in bacterial survival in kidney at 200 mg/kg, ip administered every 12 hrs for 108 hrs followed by bacterial challenge after first 12 hrs of compound dosing measured 5 days post infection | Staphylococcus aureus | 2 | ALA3826951 | organism-based format | Scientific Literature | |
6. | ALA3830158 | Functional | Attenuation of methicillin-resistant Staphylococcus aureus Mu 50 virulence in BALB/c mouse systemic infection model assessed as decrease in bacterial survival in kidney at 50 mg/kg, ip administered every 12 hrs for 108 hrs followed by bacterial challenge after first 12 hrs of compound dosing measured 5 days post infection | Staphylococcus aureus | 2 | ALA3826951 | organism-based format | Scientific Literature | |
7. | ALA3830163 | Binding | Inhibition of Staphylococcus aureus ATCC 27659 full length His-tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in staphyloxanthin pigment formation after 72 hrs by spectrophotometric analysis | Staphylococcus aureus | 1 | ALA3826951 | cell-based format | Scientific Literature | |
8. | ALA808970 | Binding | Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]FPP as radioligand | 25 | ALA1129470 | assay format | Scientific Literature | ||
9. | ALA784697 | Functional | Compound was tested for inhibition of cholesterol biosynthesis in rats by intravenous (iv) dosing. | Rattus norvegicus | 7 | ALA1129471 | organism-based format | Scientific Literature | |
10. | ALA880206 | Functional | Compound was tested for inhibition of cholesterol biosynthesis in rats by oral dosing (po). | Rattus norvegicus | 14 | ALA1129471 | organism-based format | Scientific Literature | |
11. | ALA779633 | Functional | In vivo effective dose against Cholesterol Biosynthesis in rats by oral administration | Rattus norvegicus | 1 | ALA1129470 | organism-based format | Scientific Literature | |
12. | ALA781991 | Functional | In vivo intravenous effective dose against cholesterol biosynthesis in rats | Rattus norvegicus | 12 | ALA1129470 | organism-based format | Scientific Literature | |
13. | ALA941163 | Binding | Inhibition of Staphylococcus aureus dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectrophotometric assay | Staphylococcus aureus | 38 | ALA1140905 | cell-based format | Scientific Literature | |
14. | ALA941164 | Functional | Inhibition of staphyloxanthin biosynthesis in Staphylococcus aureus Pig1 isolate after 72 hrs | Staphylococcus aureus | 38 | ALA1140905 | organism-based format | Scientific Literature | |
15. | ALA941165 | Binding | Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21 (DE3) cells assessed as formation of 1,10-dioic acid metabolite by liquid scintillation | Homo sapiens | 38 | ALA1140905 | cell-based format | Scientific Literature | |
16. | ALA4008294 | Binding | Inhibition of Staphylococcus aureus ATCC 27659 histidine-tagged full length CrtM expressed in Escherichia coli BL21(DE3) cells assessed as decrease in staphyloxanthin formation after 30 mins by continous spectrophotometric method | Staphylococcus aureus | 1 | ALA4007400 | cell-based format | Scientific Literature | |
17. | ALA4027795 | Binding | Inhibition of CrtM in Staphylococcus aureus assessed as reduction in staphyloxanthin levels after 72 hrs by spectrophotometric method | Staphylococcus aureus | 1 | ALA4024779 | single protein format | Scientific Literature |