# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5042806 | B | Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET assay | Homo sapiens | 58 | single protein format | Scientific Literature | ||
2. | ALA5042807 | B | Inhibition of CDK9 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET assay | Homo sapiens | 27 | single protein format | Scientific Literature | ||
3. | ALA5042808 | B | Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET assay | Homo sapiens | 20 | single protein format | Scientific Literature | ||
4. | ALA5042809 | B | Inhibition of wild type full length DYRK1A (unknown origin) in human U2OS cells assessed as reduction in pSER520 autophosphorylation incubated for 5 hrs by western blot analysis | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
5. | ALA5042817 | B | Binding affinity to DYRK1B (unknown origin) assessed as binding constant | Homo sapiens | 2 | single protein format | Scientific Literature | ||
6. | ALA5042818 | B | Binding affinity to CLK1 (unknown origin) assessed as binding constant | Homo sapiens | 2 | single protein format | Scientific Literature | ||
7. | ALA5042819 | B | Binding affinity to CLK2 (unknown origin) assessed as binding constant | Homo sapiens | 2 | single protein format | Scientific Literature | ||
8. | ALA5042820 | B | Binding affinity to CLK4 (unknown origin) assessed as binding constant | Homo sapiens | 2 | single protein format | Scientific Literature | ||
9. | ALA5042826 | F | Antitumor activity against human RS4-11 cells xenografted in BALB/c nu/nu mouse assessed as reduction in DYRK1A autophosphorylation of S520 residue at 6.25 mg/kg, po measured after 2 hrs by western blotting analysis relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
10. | ALA5042827 | F | Antitumor activity against human RS4-11 cells xenografted in BALB/c nu/nu mouse reduction in DYRK1A autophosphorylation of S520 residue at 6.25 mg/kg, po measured after 6 hrs by western blotting analysis relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
11. | ALA5042841 | F | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA5042842 | F | Antiproliferative activity against human SK-N-MC cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA5042843 | F | Antiproliferative activity against human C-33-A cells assessed as reduction in cell viability incubated for 120 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
14. | ALA5042844 | F | Antiproliferative activity against human A2780 cells assessed as reduction in cell viability by soft agar assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
15. | ALA5042845 | F | Antiproliferative activity against human SK-N-MC cells assessed as reduction in cell viability by soft agar assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA5042846 | F | Antiproliferative activity against human C-33-A cells assessed as reduction in cell viability by soft agar assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA5251363 | B | Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
18. | ALA5251364 | B | Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
19. | ALA5251365 | B | Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature | ||
20. | ALA5251366 | B | Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | Homo sapiens | 56 | cell-based format | Scientific Literature |