# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5040019 | T | Cytotoxicity against human THP1-Dual cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay | Homo sapiens | 47 | ALA5038595 | cell-based format | Scientific Literature | |
2. | ALA5040020 | B | Inhibition of human cGAS expressed in THP1-Dual cells transfected with HT-DNA assessed as suppression of lipofectamine 2000:ds-DNA complex induced activation of cGAS incubated for 1 hr by Quanti-luc reagent based assay | Homo sapiens | 47 | ALA5038595 | cell-based format | Scientific Literature | |
3. | ALA5040021 | T | Cytotoxicity against mouse RAW-Lucia ISG cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay | Mus musculus | 25 | ALA5038595 | cell-based format | Scientific Literature | |
4. | ALA5040022 | B | Inhibition of mouse cGAS expressed in RAW-Lucia ISG transfected with HT-DNA assessed as suppression of lipofectamine 2000:ds-DNA complex induced activation of cGAS incubated for 1 hr by Quanti-luc reagent based assay | Mus musculus | 25 | ALA5038595 | cell-based format | Scientific Literature | |
5. | ALA5040023 | B | Inhibition of STING-dependent cGAS activation in cGAMP treated human THP-1-Dual cells assessed as suppression of lipofectamine 2000:cGAMP-induced IRF luciferase expression at 10 uM incubated for 1 hr by Quanti-luc reagent based assay | Homo sapiens | 8 | ALA5038595 | cell-based format | Scientific Literature | |
6. | ALA5040024 | B | Inhibition of ds-DNA induced cGAS-STING signalling activation in human THP-1-Dual cells assessed as inhibition of STING phosphorylation at Ser366 residue incubated for 1 hr followed by transfection with ds-DNA and measured after 2 hrs by Western blot analysis | Homo sapiens | 2 | ALA5038595 | cell-based format | Scientific Literature | |
7. | ALA5040025 | B | Inhibition of ds-DNA induced cGAS-STING signalling activation in human THP-1-Dual cells assessed as suppression of TBK1 phosphorylation at 0.4 to 10 uM incubated for 1 hr followed by transfection with ds-DNA and measured after 2 hrs by Western blot analysis | Homo sapiens | 2 | ALA5038595 | cell-based format | Scientific Literature | |
8. | ALA5040026 | B | Inhibition of ds-DNA induced cGAS-STING signalling activation in human THP-1-Dual cells assessed as suppression of IRF3 phosphorylation at Ser386 residue at 0.4 to 10 uM incubated for 1 hr followed by transfection with ds-DNA and measured after 2 hrs by Western blot analysis | Homo sapiens | 2 | ALA5038595 | cell-based format | Scientific Literature |