# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5050275 | P | Kinetic aqueous solubility of the compound in PBS at pH 7.4 for 24 hrs by UHPLC analysis | 10 | ALA5046314 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA5050277 | F | Antitrypanosomal activity against bloodstream Trypanosoma congolense IL3000 assessed as parasite growth inhibition incubated for 69 hrs by resazurin dye based fluorescence analysis | Trypanosoma congolense | 8 | ALA5046314 | organism-based format | Scientific Literature | |
3. | ALA5050278 | F | Antitrypanosomal activity against bloodstream Trypanosoma vivax STIB 719/ ILRAD 560 assessed as parasite growth inhibition incubated for 45 hrs by resazurin dye based fluorescence analysis | Trypanosoma vivax | 8 | ALA5046314 | assay format | Scientific Literature | |
4. | ALA5050281 | A | Metabolic stability in bovine liver microsomes assessed as intrinsic clearance at 0.5 uM measured up to 30 mins by UPLC-MS/MS analysis | Bos taurus | 11 | ALA5046314 | microsome format | Scientific Literature | |
5. | ALA5050305 | T | Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 69 hrs by resazurin dye based fluorescence analysis | Rattus norvegicus | 8 | ALA5046314 | cell-based format | Scientific Literature | |
6. | ALA5050306 | F | Antitrypanosomal activity against bloodstream Trypanosoma congolense IL3000 infected in NMRI mouse assessed as reduction in parasitemia at 10 mg/kg, sc administered once daily for 4 days | Trypanosoma congolense | 7 | ALA5046314 | organism-based format | Scientific Literature | |
7. | ALA5050308 | F | Antitrypanosomal activity against bloodstream Trypanosoma vivax STIB 719/ ILRAD 560 infected in NMRI mouse assessed as reduction in parasitemia at 10 mg/kg, sc administered for 4 days | Trypanosoma vivax | 9 | ALA5046314 | organism-based format | Scientific Literature |