# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5051596 | P | Solubility of compound in PBS | 26 | small-molecule physicochemical format | Patent Bioactivity Data | |||
2. | ALA5051597 | A | Half-life in rat at 1 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Patent Bioactivity Data | ||
3. | ALA5051598 | F | Induction of mitophagy in human HeLa MKYP cells treated at 6.3 uM with FCCP/oligomycin for 6 hrs and measured by FACS analysis relative to control | Homo sapiens | 24 | cell-based format | Patent Bioactivity Data | ||
4. | ALA5051599 | F | Induction of mitophagy in human HeLa MKYP cells treated with FCCP/oligomycin for 6 hrs and measured by FACS analysis | Homo sapiens | 79 | cell-based format | Patent Bioactivity Data | ||
5. | ALA5051600 | T | Cytotoxicity against human HeLa MKYP cells assessed as percentage of DAPI-positive cells at 50 uM and measured by DAPI staining method | Homo sapiens | 100 | cell-based format | Patent Bioactivity Data | ||
6. | ALA5051601 | T | Cytotoxicity against human HeLa MKYP cells assessed as cell death at 25 uM treated with FCCP/oliogmycin and measured DAPI staining method assay relative to control | Homo sapiens | 28 | cell-based format | Patent Bioactivity Data | ||
7. | ALA5051602 | T | Cytotoxicity against human HeLa MKYP cells assessed as cell death at 25 uM and measured DAPI staining method assay relative to control | Homo sapiens | 28 | cell-based format | Patent Bioactivity Data | ||
8. | ALA5051603 | F | Ratio of highest compound concentration with no observable mitotoxicity to EC50 of compound to induce mitophagy in human HeLa MKYP cells | 11 | cell-based format | Patent Bioactivity Data | |||
9. | ALA5051604 | B | Activation of PINK1 in human HeLa cells stably expressing YFP parkin assessed as reduction in dOTC protein accumulation and measured by ornithine carbamoyltransferase (DOTC) assay relative to control | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
10. | ALA5051605 | B | Activation of PINK1 in human HeLa MKYP cells expressing PINK1 treated with FCCP/oilgomycin assessed as increase in pS65 Ub and measured by ELISA assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
11. | ALA5051606 | B | Activation of PINK1 in human HeLa MKYP PINK1-knock out cells treated with FCCP/oilgomycin assessed as increase in pS65 Ub and measured by ELISA assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA5051607 | B | Activation of PINK1 in human HeLa MKYP cells expressing PINK1 treated with FCCP/oilgomycin assessed as increase in parkin recruitment and measured by ELISA assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
13. | ALA5051608 | B | Activation of PINK1 in human HeLa MKYP PINK1-knock out cells treated with FCCP/oilgomycin assessed as increase in parkin recruitment and measured by ELISA assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
14. | ALA5051609 | F | Induction of mitophagy in human HeLa MKYP cells expressing wild-type PNIK1 treated with FCCP/oligomycin for 6 hrs and measured by FACS analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
15. | ALA5051610 | F | Induction of mitophagy in human HeLa MKYP PINK1-knockout cells treated with FCCP/oligomycin for 6 hrs and measured by FACS analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
16. | ALA5051611 | B | Activation of PINK1 in human iPSC derived neurons at 3.1 to 6.2 uM assessed as reduction in pS129 alpha-synuclein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
17. | ALA5051612 | B | Activation of PINK1 in human HeLa MKYP PINK1-knock out cells at 3.125 to 6.25 uM assessed as reduction in pS129 alpha-synuclein | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
18. | ALA5051613 | A | Cmax in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
19. | ALA5051614 | A | Half-life in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Patent Bioactivity Data | ||
20. | ALA5051615 | A | Observed AUC in mouse at 1 mg/kg, iv | Mus musculus | 1 | organism-based format | Patent Bioactivity Data |