| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5047424 | A | Drug uptake in BALB/c mouse lungs assessed as AUC (0 to t) of drug at 1 mg/kg administered intranasally and measured until 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 2. | ALA5047425 | B | Inhibition of 6His tagged AURORA B (1 to 344 residue) (unknown origin) using 5FAM-GRTGRRNSI-NH2 as substrate preincubated for 30 mins followed by substrate addition and further incubated for 60 mins in presence of ATP by fluorescence polarization assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 3. | ALA5047426 | B | Inhibition of GST-fused human JAK1 (854 to 1154 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for 30 mins followed by substrate addition and further incubated for 20 mins in presence of ATP by FRET assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 4. | ALA5047427 | B | Inhibition of GST-tagged recombinant human JAK2 (808 to 1132 residues) expressed in baculovirus expression system using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for 30 mins followed by substrate addition and further incubated for 20 mins in presence of ATP by FRET assay | Homo sapiens | 31 | assay format | Scientific Literature | ||
| 5. | ALA5047428 | B | Inhibition of GST-fused human JAK3 (810 to 1100 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for 30 mins followed by substrate addition and further incubated for 20 mins in presence of ATP by FRET assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 6. | ALA5047429 | B | Inhibition of human TYK2 (888 to 1178 residues) expressed in insect cells using ULight-JAK-1 Tyr1023 peptide as substrate preincubated for 30 mins followed by substrate addition and further incubated for 30 mins in presence of ATP by FRET assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 7. | ALA5047431 | B | Inhibition of human GST/6His-tagged VEGFR2 using Biotin-aminohexyl-EEEEYFELVAKKKK-NH2 as substrate incubated for 90 mins in presence of ATP by TR-FRET assay | Homo sapiens | 22 | single protein format | Scientific Literature | ||
| 8. | ALA5047432 | P | Solubility of the compound in stimulated lung fluid at pH 6.5 measured after 4 hrs by HPLC-UV analysis | 15 | tissue-based format | Scientific Literature | |||
| 9. | ALA5047433 | A | Permeability of the compound at pH 7.4 incubated for 3 hrs by HPLC based artificial membrane permeability assay | 18 | assay format | Scientific Literature | |||
| 10. | ALA5047434 | B | Inhibition of JAK1/JAK3 signalling in human PBMC assessed as inhibition of IL-2 stimulated IFN-gamma release incubated for 1 hr followed by IL-2 stimulation by MSD assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 11. | ALA5047435 | B | Inhibition of JAK1/JAK2/TYK1 in human lung fibroblast cells assessed as IL-13 induced eotaxin production incubated for 20 to 24 hrs by MSD assay | Homo sapiens | 20 | cell-based format | Scientific Literature | ||
| 12. | ALA5047436 | A | Clearance in mouse liver microsomes | Mus musculus | 3 | microsome format | Scientific Literature | ||
| 13. | ALA5047437 | A | Clearance in human liver microsomes | Homo sapiens | 3 | microsome format | Scientific Literature | ||
| 14. | ALA5047438 | A | Clearance in mouse hepatocytes | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA5047439 | A | Clearance in human hepatocytes | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA5047440 | A | Drug uptake in BALB/c mouse lungs at 1 mg/kg administered intranasally and measured until 8 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA5047441 | A | Drug uptake in BALB/c mouse lungs assessed as unbound AUC (0 to t) of drug at 1 mg/kg administered intranasally and measured until 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 18. | ALA5047442 | A | Stability in human liver cytosol assessed as half life at 10 mM measured upto 60 mins in absence of AO inhibitor by LC-MS/MS analysis | Homo sapiens | 7 | subcellular format | Scientific Literature | ||
| 19. | ALA5047443 | A | Stability in human liver cytosol assessed as half life at 10 mM measured upto 60 mins in presence of AO inhibitor by LC-MS/MS analysis | Homo sapiens | 7 | subcellular format | Scientific Literature | ||
| 20. | ALA5047444 | A | Clearance in mouse at 1 mg/kg, administered intranasally measured upto 12 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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