| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5256457 | B | PROTAC activity at CRBN/H-PGDS in human KU812 cells assessed as induction of H-PGDS degradation by measuring decrease in H-PGDS protein expression incubated for 24 hrs by western blot analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA5256458 | P | Solubility of the compound in PBS buffer at 100 uM at pH 7.4 by UPLC/MS/MS analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA5256459 | P | Lipophilicity, logD of the compound by UPLC analysis | 8 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA5256460 | A | Apparent permeability coefficient, Papp of the compound at pH 7.4 incubated for 4 hrs by UPLC/MS/MS analysis | 8 | assay format | Scientific Literature | |||
| 5. | ALA5256461 | A | Metabolic stability of the compound in human liver microsomes incubated for 10 mins in presence of NADPH by UPLC/MS/MS analysis | Homo sapiens | 8 | microsome format | Scientific Literature | ||
| 6. | ALA5256462 | A | Metabolic stability of the compound in human liver microsomes incubated for 60 mins in presence of NADPH by UPLC/MS/MS analysis | Homo sapiens | 8 | microsome format | Scientific Literature | ||
| 7. | ALA5057131 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation measured after 6 hrs by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA5057132 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5057133 | B | PROTAC activity at H-PGDS/CRBN in human MEG01s cells assessed as H-PGDS degradation measured after 6 to 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5057134 | B | Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 11. | ALA5057135 | F | Effect on H-PGDS mRNA level in human KU812 cells measured up to 10000 pM incubated for 6 hrs by quantitative RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA5057136 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation in presence of pomalidomide measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5057137 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation in presence of MG132 at 100 pM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5057138 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as H-PGDS degradation in presence of MLN7243 at 100 pM measured after 6 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5057139 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as reduction in H-PGDS level at 100 pM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5057140 | B | PROTAC activity at H-PGDS/CRBN in human KU812 cells assessed as reduction in H-PGDS level at 10 pM measured after 6 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5057141 | F | Suppression of PGD2 production in human KU812 cells measured in presence of compound 43 up to 3000 pM incubated for 6 hrs by LC-MS analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 18. | ALA5113356 | B | Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 19. | ALA5113357 | B | PROTAC activity at CRBN/H-PGDS in human KU812 cells assessed as reduction in H-PGDS levels incubated for 24 hrs by Western blotting analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 20. | ALA5113366 | B | PROTAC activity at CRBN/H-PGDS in human KU812 cells assessed as reduction in A23187-stimulated PGD2 levels at 10 nM preincubated for 24 hrs followed by A23187 stimulation for 30 mins by ELISA analysis relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature |
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