# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5032298 | Functional | Antitumour activity against mouse MC38 cells in C57BL/6 mouse assessed as tumour growth inhibition at 60 mg/kg, ip, bid measured after 9 days relative to control | Mus musculus | 1 | ALA5030563 | organism-based format | Scientific Literature | |
2. | ALA5032299 | Functional | Antitumour activity against mouse MC38 cells in C57BL/6 mouse assessed as tumour growth inhibition at 50 mg/kg, ip, bid measured after 9 days relative to control | Mus musculus | 1 | ALA5030563 | organism-based format | Scientific Literature | |
3. | ALA5032300 | Functional | Antitumour activity against mouse MC38 cells in C57BL/6 mouse assessed as tumour growth inhibition at 30 mg/kg, ip, bid measured after 9 days relative to control | Mus musculus | 1 | ALA5030563 | organism-based format | Scientific Literature | |
4. | ALA5032301 | Binding | Inhibition of HDAC in mouse MC38 cells assessed as increase in acetyl-histone H4 measured after 24 hrs by Western blot analysis | Mus musculus | 1 | ALA5030563 | cell-based format | Scientific Literature | |
5. | ALA5032302 | Binding | Inhibition of HDAC in mouse MC38 cells assessed as increase in acetyl-histone H3 measured after 24 hrs by Western blot analysis | Mus musculus | 1 | ALA5030563 | cell-based format | Scientific Literature | |
6. | ALA5032303 | Binding | Inhibition of HDAC8 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
7. | ALA5032304 | Binding | Inhibition of HDAC11 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
8. | ALA5032305 | Binding | Inhibition of HDAC10 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
9. | ALA5032306 | Binding | Inhibition of HDAC9 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
10. | ALA5032307 | Binding | Inhibition of HDAC7 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
11. | ALA5032308 | Binding | Inhibition of HDAC4 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
12. | ALA5032309 | Binding | Inhibition of HDAC3 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
13. | ALA5032310 | Binding | Inhibition of HDAC2 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
14. | ALA5032311 | Binding | Displacement of [3H]DPCPX from human adenosine A3 receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis | Homo sapiens | 2 | ALA5030563 | cell membrane format | Scientific Literature | |
15. | ALA5032312 | Binding | Inhibition of HDAC5 (unknown origin) assessed as release of 7-amino-4-methylcoumarin incubated in room temperature for 15 min measured by Spectra max microtitre plate reader | Homo sapiens | 1 | ALA5030563 | single protein format | Scientific Literature | |
16. | ALA5032313 | Binding | Displacement of [3H]DPCPX from human adenosine A2B receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis | Homo sapiens | 2 | ALA5030563 | cell membrane format | Scientific Literature | |
17. | ALA5032314 | Binding | Displacement of [3H]DPCPX from human adenosine A1 receptor membrane (unknown origin) measured after 60 mins by scintillation counting analysis | Homo sapiens | 2 | ALA5030563 | cell membrane format | Scientific Literature | |
18. | ALA5032315 | ADME | Bioavailability in ICR mouse at 5 mg/kg up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5030563 | organism-based format | Scientific Literature | |
19. | ALA5032316 | ADME | Volume of distribution in ICR mouse at 5 mg/kg, iv up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5030563 | organism-based format | Scientific Literature | |
20. | ALA5032317 | ADME | MRT in ICR mouse at 5 mg/kg, iv up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA5030563 | organism-based format | Scientific Literature |