# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5039987 | F | Cytotoxicity against human MEC-1 cells cocultured with human PBMC cells assessed as inhibition of cell proliferation at 100 nM incubated with PBMC cells for 18 hrs followed by co-incubation with MEC-1 cells for 4 hrs by SYTOX blue staining based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA5039988 | F | Cytotoxicity against human K562 cells cocultured with human PBMC cells assessed as inhibition of cell proliferation at 100 nM incubated with PBMC cells for 18 hrs followed by co-incubation with K562 cells for 4 hrs by SYTOX blue staining based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA5039989 | F | Cytotoxicity against human MEC-1 cells cocultured with human PBMC cells assessed as inhibition of cell proliferation at 1 uM incubated with PBMC cells for 18 hrs followed by co-incubation with MEC-1 cells for 4 hrs by SYTOX blue staining based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
4. | ALA5039990 | F | Cytotoxicity against human K562 cells cocultured with human PBMC cells assessed as inhibition of cell proliferation at 1 uM incubated with PBMC cells for 18 hrs followed by co-incubation with K562 cells for 4 hrs by SYTOX blue staining based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA5039991 | F | Cytotoxicity against human MEC-1 cells cocultured with human PBMC cells assessed as inhibition of cell proliferation at 10 uM incubated with PBMC cells for 18 hrs followed by co-incubation with MEC-1 cells for 4 hrs by SYTOX blue staining based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA5039992 | F | Immunostimulatory activity in human PBMC cells assessed as increase in IL-6 production at 2 uM incubated for 18 hrs by flow cytometry analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
7. | ALA5039993 | B | Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as fold increase in NFkappaB transactivation-mediated SEAP activity at 2 uM measured after 18 hrs by spectrophotometric analysis relative to control | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
8. | ALA5039994 | F | Immunostimulatory activity in human PBMC cells assessed as increase in IL-8 production at 2 uM incubated for 18 hrs by flow cytometry analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
9. | ALA5039995 | B | Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spectrophotometric method | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
10. | ALA5039996 | F | Immunostimulatory activity in human PBMC cells assessed as increase in IL-1beta production at 2 uM incubated for 18 hrs by flow cytometry analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
11. | ALA5039997 | F | Immunostimulatory activity in human PBMC cells assessed as increase in TNF-alpha production at 2 uM incubated for 18 hrs by flow cytometry analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
12. | ALA5039998 | F | Immunostimulatory activity in human PBMC cells assessed as increase in LPS-induced IL-8 production at 2 uM incubated for 18 hrs by flow cytometry analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
13. | ALA5039999 | F | Immunostimulatory activity in human PBMC cells assessed as increase in LPS-induced IL-6 production at 2 uM incubated for 18 hrs by flow cytometry analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
14. | ALA5040000 | F | Immunostimulatory activity in human PBMC cells assessed as increase in LPS-induced IL-1beta production at 2 uM incubated for 18 hrs by flow cytometry analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
15. | ALA5040001 | F | Immunostimulatory activity in human PBMC cells assessed as increase in LPS-induced TNF-alpha production at 2 uM incubated for 18 hrs by flow cytometry analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
16. | ALA5040002 | F | Cytotoxicity against human K562 cells cocultured with human PBMC cells assessed as inhibition of cell proliferation at 10 uM incubated with PBMC cells for 18 hrs followed by co-incubation with K562 cells for 4 hrs by SYTOX blue staining based flow cytometric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA5040003 | F | Induction of mouse BMDC-mediated ovalbumin specific CD4+ T cell activation assessed as increase in CD25 expression at 10 uM incubated for 72 hrs by CFSE staining based flow cytometric analysis | Mus musculus | 2 | cell-based format | Scientific Literature | ||
18. | ALA5040011 | F | Immuno-adjuvant activity in NIH/OlaHsd mouse assessed as increase in ovalbumin specific Th1 associated IgG1 production in sera at 0.30 micromol administered subcutaneously on day 1 and as booster dose on day 21 with ovalbumin loaded neutral liposomes and measured 1 week post booster dose by ELISA | Mus musculus | 3 | organism-based format | Scientific Literature | ||
19. | ALA5040012 | F | Immuno-adjuvant activity in NIH/OlaHsd mouse assessed as increase in ovalbumin specific Th2 associated IgG2a production in sera at 0.30 micromol administered subcutaneously on day 1 and as booster dose on day 21 with ovalbumin loaded neutral liposomes and measured 1 week post booster dose by ELISA | Mus musculus | 3 | organism-based format | Scientific Literature | ||
20. | ALA5040013 | F | Immuno-adjuvant activity in NIH/OlaHsd mouse assessed as increase in ovalbumin specific IgG production in sera at 0.15 micromol administered subcutaneously on day 1 and as booster dose on day 21 and 28 with ovalbumin loaded liposomes by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature |