# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5041938 | B | Inhibition of JAK1/TYK2 in human H9 cells assessed as inhibition of IFNalpha-stimulated STAT1 phosphorylation at 5000 nM measured after 1 hr by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA5041939 | B | Inhibition of JAK1/JAK3 in human THP-1 cells assessed as inhibition of IL-4-stimulated STAT6 phosphorylation at 5000 nM measured after 1 hr by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA5041940 | B | Inhibition of human recombinant TYK2 (875 to end residues) using GGMEDIYFEFMGG as substrate incubated for 40 min in presence of ATP measured by scintillation counting based radiometry assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
4. | ALA5041941 | T | Cytotoxicity against human LO2 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA5041942 | B | Inhibition of JAK1 (unknown origin) | Homo sapiens | 27 | single protein format | Scientific Literature | ||
6. | ALA5041943 | B | Inhibition of JAK2 (unknown origin) | Homo sapiens | 27 | single protein format | Scientific Literature | ||
7. | ALA5041944 | B | Inhibition of JAK3 (unknown origin) | Homo sapiens | 26 | single protein format | Scientific Literature | ||
8. | ALA5041945 | B | Inhibition of TYK2 (unknown origin) | Homo sapiens | 27 | single protein format | Scientific Literature | ||
9. | ALA5041946 | A | Metabolic stability in human liver microsomes | Homo sapiens | 3 | microsome format | Scientific Literature | ||
10. | ALA5041947 | A | Cmax in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
11. | ALA5041948 | A | Clearance in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
12. | ALA5041949 | A | Half life in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
13. | ALA5041950 | A | AUC (0 to 24 hrs) in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
14. | ALA5041951 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
15. | ALA5041952 | B | Inhibition of human recombinant full length Aurora-A using LRRASLG as substrate incubated for 40 min measured by scintillation counting based radiometry assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
16. | ALA5041953 | B | Inhibition of human recombinant JAK1 (866 to end residues) using GEEPLYWSFPAKK as substrate incubated for 40 min in presence of ATP measured by scintillation counting based radiometry assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
17. | ALA5041954 | B | Inhibition of human recombinant JAK2 (808 to end residues) using KTFCGTPEYLAPE as substrate incubated for 40 min in presence of ATP measured by scintillation counting based radiometry assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
18. | ALA5041955 | B | Inhibition of human recombinant JAK3 (781 to end residues) using GGEEEEYFELVKK as substrate incubated for 40 min in presence of ATP measured by scintillation counting based radiometry assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
19. | ALA5041956 | B | Inhibition of JAK2 in human TF-1 cells assessed as inhibition of GM-CSF-stimulated STAT5 phosphorylation at 5000 nM measured after 1 hr by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA5041957 | B | Inhibition of JAK1/JAK2/TYK2 in human TF-1 cells assessed as inhibition of rhIL-6-stimulated STAT3 phosphorylation at 5000 nM measured after 1.5 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |