| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5053965 | B | Inhibition of recombinant METLL3 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in N6-methyladenosine level in oligonucleotide substrate by TR-FRET assay | Homo sapiens | 23 | cell-based format | Scientific Literature | ||
| 2. | ALA5053966 | P | Kinetic solubility of the compound in PBS at pH 7.4 at 100 uM incubated for 1 hr by LCMS/MS analysis | 22 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA5053967 | A | Efflux ratio of apparent permeability in human Caco-2 cells at 10 uM measured after 90 mins using fluorometry | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 4. | ALA5053968 | A | Metabolic stability in rat liver microsomes assessed as half life by LC-MS analysis | Rattus norvegicus | 22 | microsome format | Scientific Literature | ||
| 5. | ALA5053972 | B | Binding affinity to human METTL3/METLL14 assessed as change in melting temperature at 100 uM by thermal shift assay | Homo sapiens | 1 | protein complex format | Scientific Literature | ||
| 6. | ALA5053973 | B | Binding affinity to human METTL16 assessed as change in melting temperature at 100 uM by thermal shift assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA5053974 | B | Binding affinity to human METTL1 assessed as change in melting temperature at 100 uM by thermal shift assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA5053975 | B | Thermal stabilization of recombinant METTL3 (354 to 580 residues) (unknown origin) expressed in HEK293T cells assessed as non-aggregated METTL3-ePL protein incubated for 1 hr and cells heated 46 degC by luminescence-based InCELL Pulse assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5053976 | B | Thermal stabilization of endogenously expressing full length METTL3 in human MOLM-13 cells assessed as stabilized METTL3 incubated for at 54 degC by Western blotting based CETSA assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5053977 | F | Reduction in m6A/A ratio in poly-adenylated RNA fraction of human MOLM-13 cells measured after 16 hrs by UPLC-MS/MS analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA5053978 | F | Reduction in m6A/A ratio in poly-adenylated RNA fraction of human PC-3 cells measured after 16 hrs by UPLC-MS/MS analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA5053979 | F | Growth inhibition of human MOLM-13 cells assessed as cell viability measured after 3 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5053980 | F | Growth inhibition of human PC-3 cells assessed as cell viability measured after 3 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5053981 | F | Effect on METTL3 expression in human MOLM-13 cells at 10 uM incubated for 16 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5053982 | F | Effect on METTL3 expression in human PC-3 cells at 10 uM incubated for 16 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA5053983 | F | Reduction in m6A levels in mRNA fraction in human MOLM-13 cells at 10 uM measured after 6 days by UPLC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5053984 | F | Reduction in m1A levels in mRNA fraction in human MOLM-13 cells at 10 uM measured after 6 days by UPLC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5053985 | F | Reduction in m7G levels in mRNA fraction in human MOLM-13 cells at 10 uM measured after 6 days by UPLC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5053986 | F | Reduction in m6A levels in total RNA fraction in human MOLM-13 cells at 10 uM measured after 6 days by UPLC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5053987 | F | Reduction in m6Am levels in total RNA fraction in human MOLM-13 cells at 10 uM measured after 6 days by UPLC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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