# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5049075 | B | Inhibition of human GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometry | Homo sapiens | 26 | ALA5046282 | single protein format | Scientific Literature | |
2. | ALA5049076 | P | 1-Octanol/aqueous buffer partition coefficient, logD of the compound at pH 7.4 by chromatographic method | 18 | ALA5046282 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA5049077 | P | Kinetic solubility of the compound in JP2 fluid at pH 6.8 by precipitation method | 9 | ALA5046282 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA5049078 | A | Intrinsic clearance in mouse liver microsomes at 1 uM in presence of NADPH generating system assessed per mg protein by LC-MS/MS analysis | Mus musculus | 12 | ALA5046282 | microsome format | Scientific Literature | |
5. | ALA5049079 | T | Inhibition of hERG expressed in CHO-K1 cells at 10 uM incubated for 5 mins by whole cell-automated voltage clamp analysis | Homo sapiens | 6 | ALA5046282 | cell-based format | Scientific Literature | |
6. | ALA5049080 | A | Efflux ratio of apparent permeability from basolateral to apical side over apical to basolateral side in dog MDCK-MDR1 cells at 1 uM measured after 1 hr by LC-MS/MS analysis | Canis lupus familiaris | 12 | ALA5046282 | cell-based format | Scientific Literature | |
7. | ALA5049081 | B | Inhibition of mouse GCS using C8-ceramide and UDP-glucose as substrate incubated for 1 hr by RapidFire mass spectrometry | Mus musculus | 2 | ALA5046282 | single protein format | Scientific Literature | |
8. | ALA5049082 | A | Intrinsic clearance in human liver microsomes at 1 uM in presence of NADPH generating system assessed per mg protein by LC-MS/MS analysis | Homo sapiens | 2 | ALA5046282 | microsome format | Scientific Literature | |
9. | ALA5049083 | A | Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate at 10 uM in presence of NADPH generating system incubated for 10 mins | Homo sapiens | 2 | ALA5046282 | microsome format | Scientific Literature | |
10. | ALA5049084 | A | Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate at 10 uM in presence of NADPH generating system incubated for 10 mins | Homo sapiens | 2 | ALA5046282 | microsome format | Scientific Literature | |
11. | ALA5049085 | A | Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate at 10 uM in presence of NADPH generating system incubated for 10 mins | Homo sapiens | 2 | ALA5046282 | microsome format | Scientific Literature | |
12. | ALA5049086 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate at 10 uM in presence of NADPH generating system incubated for 10 mins | Homo sapiens | 2 | ALA5046282 | microsome format | Scientific Literature | |
13. | ALA5049087 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate at 10 uM in presence of NADPH generating system incubated for 10 mins | Homo sapiens | 2 | ALA5046282 | microsome format | Scientific Literature | |
14. | ALA5049088 | A | Plasma clearance in non-fasted ICR mouse at 0.5 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 2 | ALA5046282 | organism-based format | Scientific Literature | |
15. | ALA5049089 | A | Volume of distribution at steady state in non-fasted ICR mouse at 0.5 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 2 | ALA5046282 | organism-based format | Scientific Literature | |
16. | ALA5049090 | A | MRT in non-fasted ICR mouse at 0.5 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 2 | ALA5046282 | organism-based format | Scientific Literature | |
17. | ALA5049091 | A | Cmax in non-fasted ICR mouse at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 2 | ALA5046282 | organism-based format | Scientific Literature | |
18. | ALA5049092 | A | AUC in non-fasted ICR mouse at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 2 | ALA5046282 | organism-based format | Scientific Literature | |
19. | ALA5049093 | A | MRT in non-fasted ICR mouse at 5 mg/kg, po by LC-MS/MS analysis | Mus musculus | 2 | ALA5046282 | organism-based format | Scientific Literature | |
20. | ALA5049094 | A | Fraction unbound in plasma of non-fasted ICR mouse at 30 mg/kg, po measured after 1 hr by LC-MS/MS analysis | Mus musculus | 2 | ALA5046282 | organism-based format | Scientific Literature |