| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5039969 | B | Protac activity at CRBN/EGFR in human SW1990 cells assessed as induction of EGFR degradation at 1 to 50 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA5039970 | B | Protac activity at CRBN/PARP-1 in human SW1990 cells assessed as induction of PARP-1 degradation at 1 to 50 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA5039971 | B | Protac activity at CRBN/EGFR in human SW1990 cells assessed as induction of EGFR degradation at 5 uM measured after 6 to 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5039972 | B | Protac activity at CRBN/PARP-1 in human SW1990 cells assessed as induction of PARP-1 degradation at 5 uM measured after 6 to 48 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5039973 | B | Protac activity at CRBN/EGFR in human SW1990 cells assessed as decrease in EGFR expression level at 1 to 50 uM pretreated with proteasome inhibitor MG132 for 4 hr followed by incubation with compound for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5039974 | B | Protac activity at CRBN/PARP-1 in human SW1990 cells assessed as decrease of PARP-1 expression level at 1 to 50 uM pretreated with proteasome inhibitor MG132 for 4 hr followed by incubation with compound for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5039985 | B | Binding affinity to recombinant human His/GST tagged EFGR (668 to 1220 residues) expressed in baculovirus infected cells assessed as dissociation constant incubated for 30 mins by microscale thermophoresis analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA5039986 | B | Binding affinity to human GST-tagged PARP-1 ART domain (788 to 1014 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant incubated for 30 mins by microscale thermophoresis analysis | Homo sapiens | 3 | assay format | Scientific Literature |
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