# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5038057 | B | Inhibition of Mycobacterium tuberculosis Pks13-TE domain using 4-methylumbelliferyl heptanoate as a fluorogenic substrate measured for 110 mins at 10 mins interval | Mycobacterium tuberculosis | 38 | ALA5036355 | single protein format | Scientific Literature | |
2. | ALA5038058 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv | Mycobacterium tuberculosis | 38 | ALA5036355 | organism-based format | Scientific Literature | |
3. | ALA5038059 | F | Antimycobacterial activity against Mycobacterium tuberculosis infected in THP1 monocytes assessed as inhibition of luciferase luminescence signal | Mycobacterium tuberculosis | 10 | ALA5036355 | organism-based format | Scientific Literature | |
4. | ALA5038060 | F | In vivo antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in C57BL/6 mouse assessed as 2 log10 reduction in colony-forming unit in lung respect to untreated to control | Mycobacterium tuberculosis | 3 | ALA5036355 | organism-based format | Scientific Literature | |
5. | ALA5038061 | B | Inhibition of hERG ion channel by Q patch-clamp method | Homo sapiens | 37 | ALA5036355 | single protein format | Scientific Literature | |
6. | ALA5038063 | A | Intrinsic microsomal clearance in CDI mouse liver microsomes | Mus musculus | 38 | ALA5036355 | microsome format | Scientific Literature | |
7. | ALA5038064 | P | Lipophilicity, CHI-log D of the compound at pH 7.4 by HPLC-UV analysis | 38 | ALA5036355 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA5038069 | A | Cmax in CD1 mouse plasma at 75 mg/kg measured after 24 hrs | Mus musculus | 2 | ALA5036355 | organism-based format | Scientific Literature | |
9. | ALA5038072 | A | AUC in CD1 mouse plasma at 75 mg/kg measured after 24 hrs | Mus musculus | 2 | ALA5036355 | organism-based format | Scientific Literature | |
10. | ALA5038074 | T | Cardiotoxicity in 0.5 Hz frequency stimulated New Zealand white rabbit heart assessed as assessed as change in QRS level at 30 uM by RVW assay | Oryctolagus cuniculus | 2 | ALA5036355 | tissue-based format | Scientific Literature | |
11. | ALA5038075 | T | Cardiotoxicity in 0.5 Hz frequency stimulated New Zealand white rabbit heart assessed as assessed as change in QT level at 30 uM by RVW assay | Oryctolagus cuniculus | 2 | ALA5036355 | tissue-based format | Scientific Literature | |
12. | ALA5038076 | T | Cardiotoxicity in 0.5 Hz frequency stimulated New Zealand white rabbit heart assessed as assessed as change in Tp-e level at 30 uM by RVW assay | Oryctolagus cuniculus | 2 | ALA5036355 | tissue-based format | Scientific Literature | |
13. | ALA5038077 | T | Cardiotoxicity in 0.5 Hz frequency stimulated New Zealand white rabbit heart assessed as assessed as change in Tdp score at 30 uM by RVW assay | Oryctolagus cuniculus | 2 | ALA5036355 | tissue-based format | Scientific Literature | |
14. | ALA5038078 | T | Toxicity in C57BL/6 mouse chronic Mycobacterium tuberculosis infection model assessed as tolerability at 500 mg/kg, po treated 5 days per week from day 28 to day 56 post infection | Mus musculus | 2 | ALA5036355 | organism-based format | Scientific Literature | |
15. | ALA5038079 | A | Inhibition of human Nav1.5 at 30 uM comprehensive in-vitro proarrhythmia assay | Homo sapiens | 1 | ALA5036355 | single protein format | Scientific Literature | |
16. | ALA5038080 | A | Inhibition of human Kv4.3/KChIP2 at 30 uM comprehensive in-vitro proarrhythmia assay | Homo sapiens | 1 | ALA5036355 | protein complex format | Scientific Literature | |
17. | ALA5038081 | A | Inhibition of human Cav1.2 at 30 uM comprehensive in-vitro proarrhythmia assay | Homo sapiens | 1 | ALA5036355 | single protein format | Scientific Literature | |
18. | ALA5038082 | A | Inhibition of human hKv1.5 at 30 uM comprehensive in-vitro proarrhythmia assay | Homo sapiens | 1 | ALA5036355 | single protein format | Scientific Literature | |
19. | ALA5038083 | A | Inhibition of human KCNQ1 at 30 uM comprehensive in-vitro proarrhythmia assay | Homo sapiens | 1 | ALA5036355 | single protein format | Scientific Literature | |
20. | ALA5038084 | A | Inhibition of hERG at 30 uM comprehensive in-vitro proarrhythmia assay | Homo sapiens | 1 | ALA5036355 | single protein format | Scientific Literature |