| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5051246 | B | Positive allosteric modulation of recombinant N-terminal poly-His tagged rat neurolysin using Mca-Pro-Leu- Gly-Pro-D-Lys(DNP)-OH as substrate and measured by fluorescence based assay | Rattus norvegicus | 44 | assay format | Patent Bioactivity Data | ||
| 2. | ALA5051247 | B | Positive allosteric modulation of recombinant N-terminal poly-His tagged rat neurolysin using Mca-Pro-Leu- Gly-Pro-D-Lys(DNP)-OH as substrate assessed as Amax and measured by fluorescence based assay relative to control | Rattus norvegicus | 44 | assay format | Patent Bioactivity Data | ||
| 3. | ALA5237344 | B | Activation of recombinant rat Neurolysin using QFS as substrate incubated for 10 mins | Rattus norvegicus | 62 | single protein format | Scientific Literature | ||
| 4. | ALA5237345 | B | Activation of recombinant rat Neurolysin assessed as maximum activation using QFS as substrate incubated for 10 mins relative to control | Rattus norvegicus | 62 | single protein format | Scientific Literature | ||
| 5. | ALA5237346 | A | Metabolic stability in mouse plasma assessed as half life measured upto 240 mins by LC-MS/MS analysis | Mus musculus | 5 | cell-free format | Scientific Literature | ||
| 6. | ALA5237347 | A | Metabolic stability in mouse brain homogenate assessed as half life measured upto 240 mins by LC-MS/MS analysis | Mus musculus | 5 | tissue-based format | Scientific Literature | ||
| 7. | ALA5237348 | A | Protein binding in mouse plasma assessed as unbound fraction measured after 4 hrs by equilibrium dialysis analysis | Mus musculus | 5 | cell-free format | Scientific Literature | ||
| 8. | ALA5237349 | A | Protein binding in mouse brain assessed as unbound fraction measured after 4 hrs by equilibrium dialysis analysis | Mus musculus | 5 | tissue-based format | Scientific Literature | ||
| 9. | ALA5237350 | A | Permeability coefficient across apical to basolateral side in mouse BEND3 cells co-cultured with mouse primary astrocytes incubated for 120 mins by LC-MS/MS analysis | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA5237352 | B | Inhibition of recombinant human THOP catalytic activity at 100 uM using Mca-Pro-Leu-Gly-Pro-D-Lys(DNP)-OH as substrate | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA5237353 | B | Inhibition of recombinant human NEP catalytic activity using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH as substrate | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 12. | ALA5237354 | B | Inhibition of recombinant human ACE2 catalytic activity at 300 uM using Mca-Ala-Pro-Lys-(Dnp)-OH as substrate | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 13. | ALA5237355 | B | Inhibition of recombinant human ACE catalytic activity measured up to 150 uM | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 14. | ALA5237356 | B | Activation of recombinant rat Neurolysin assessed as interference of fluorescent signal using QFS as substrate | Rattus norvegicus | 3 | single protein format | Scientific Literature | ||
| 15. | ALA5237357 | B | Activation of recombinant rat Neurolysin assessed as formation of bradykinin (1 to 5) from bradykinin by measuring substrate preincubated for 10 mins followed by substrate addition and measured for 10 mins hydrolysis by LC-MS/MS analysis | Rattus norvegicus | 3 | single protein format | Scientific Literature | ||
| 16. | ALA5237358 | B | Activation of recombinant rat Neurolysin assessed as formation of neurotensin (1 to 10) from neurotensin by measuring substrate preincubated for 10 mins followed by substrate addition and measured for 10 mins hydrolysis by LC-MS/MS analysis | Rattus norvegicus | 3 | single protein format | Scientific Literature |
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