# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5035498 | ADME | Permeability of compound by PAMPA-BBB assay | 2 | ALA5034025 | assay format | Scientific Literature | ||
2. | ALA5035499 | Binding | Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry | Homo sapiens | 92 | ALA5034025 | single protein format | Scientific Literature | |
3. | ALA5035500 | Functional | Antialzheimer activity in human Amyloid beta (3 to 40)-induced acute Alzheimer disease ICR mouse model assessed as inhibition of AbetaN3pE-40 level formation at 10 mM, icv by ELISA | Mus musculus | 2 | ALA5034025 | organism-based format | Scientific Literature | |
4. | ALA5035501 | Functional | Antialzheimer activity in human Amyloid beta (3 to 40)-induced acute Alzheimer disease ICR mouse model assessed as inhibition of AbetaN3pE-40 level formation at 25 mg/kg, ip by ELISA | Mus musculus | 2 | ALA5034025 | organism-based format | Scientific Literature | |
5. | ALA5035502 | Binding | Inhibition of isoQC (unknown origin) | Homo sapiens | 2 | ALA5034025 | single protein format | Scientific Literature | |
6. | ALA5035503 | Binding | Inhibition of mouse QPCT measured after 15 mins by fluorimetry | Mus musculus | 2 | ALA5034025 | single protein format | Scientific Literature | |
7. | ALA5035504 | ADME | Cytotoxicity against mouse HT22 cells assessed as cell viability at 10 uM incubated for 18 hrs by MTT assay | Mus musculus | 2 | ALA5034025 | cell-based format | Scientific Literature | |
8. | ALA5035505 | Binding | Inhibition of human ERG at 10 uM by fluorescence polarization assay | Homo sapiens | 2 | ALA5034025 | single protein format | Scientific Literature | |
9. | ALA5035506 | ADME | Inhibition of CYP1A2 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA5034025 | single protein format | Scientific Literature | |
10. | ALA5035507 | ADME | Inhibition of CYP2C9 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA5034025 | single protein format | Scientific Literature | |
11. | ALA5035508 | ADME | Inhibition of CYP2C19 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA5034025 | single protein format | Scientific Literature | |
12. | ALA5035509 | ADME | Inhibition of CYP2D6 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA5034025 | single protein format | Scientific Literature | |
13. | ALA5035510 | ADME | Inhibition of CYP3A4 (unknown origin) at 10 uM | Homo sapiens | 2 | ALA5034025 | single protein format | Scientific Literature | |
14. | ALA5035511 | ADME | Metabolic stability in mouse liver microsomes assessed as parent compound remaining measured after 30 mins | Mus musculus | 2 | ALA5034025 | microsome format | Scientific Literature | |
15. | ALA5035512 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining measured after 30 mins | Homo sapiens | 2 | ALA5034025 | microsome format | Scientific Literature | |
16. | ALA5035513 | Functional | Antialzheimer activity in transgenic 5XFAD mouse model assessed as amyloid betaN3pE-40 levels in hippocampus at 10 mM administered every day for 4 weeks via brain infusion by ELISA | Mus musculus | 1 | ALA5034025 | organism-based format | Scientific Literature | |
17. | ALA5035514 | Functional | Antialzheimer activity in transgenic 5XFAD mouse model assessed as amyloid betaN3pE-42 levels in hippocampus at 10 mM administered every day for 4 weeks via brain infusion by ELISA | Mus musculus | 1 | ALA5034025 | organism-based format | Scientific Literature | |
18. | ALA5035515 | Functional | Antialzheimer activity in transgenic 5XFAD mouse model assessed as amyloid beta40 levels in hippocampus at 10 mM administered every day for 4 weeks via brain infusion by ELISA | Mus musculus | 1 | ALA5034025 | organism-based format | Scientific Literature | |
19. | ALA5035516 | Functional | Antialzheimer activity in transgenic 5XFAD mouse model assessed as amyloid beta42 levels in hippocampus at 10 mM administered every day for 4 weeks via brain infusion by ELISA | Mus musculus | 1 | ALA5034025 | organism-based format | Scientific Literature | |
20. | ALA5035517 | Functional | Antialzheimer activity against transgenic 5XFAD mouse assessed as reversal of behavioral effect by measuring total arm entries at 10 mM for 4 weeks via brain infusion by Y-maze test | Mus musculus | 1 | ALA5034025 | organism-based format | Scientific Literature |