# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5035498 | A | Permeability of compound by PAMPA-BBB assay | 2 | assay format | Scientific Literature | |||
2. | ALA5035499 | B | Inhibition of human recombinant glutaminyl cyclase using H-Gln-AMC hydrobromide as substrate measured after 15 mins by fluorimetry | Homo sapiens | 92 | single protein format | Scientific Literature | ||
3. | ALA5035500 | F | Antialzheimer activity in human Amyloid beta (3 to 40)-induced acute Alzheimer disease ICR mouse model assessed as inhibition of AbetaN3pE-40 level formation at 10 mM, icv by ELISA | Mus musculus | 2 | organism-based format | Scientific Literature | ||
4. | ALA5035501 | F | Antialzheimer activity in human Amyloid beta (3 to 40)-induced acute Alzheimer disease ICR mouse model assessed as inhibition of AbetaN3pE-40 level formation at 25 mg/kg, ip by ELISA | Mus musculus | 2 | organism-based format | Scientific Literature | ||
5. | ALA5035502 | B | Inhibition of isoQC (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
6. | ALA5035503 | B | Inhibition of mouse QPCT measured after 15 mins by fluorimetry | Mus musculus | 2 | single protein format | Scientific Literature | ||
7. | ALA5035504 | A | Cytotoxicity against mouse HT22 cells assessed as cell viability at 10 uM incubated for 18 hrs by MTT assay | Mus musculus | 2 | cell-based format | Scientific Literature | ||
8. | ALA5035505 | B | Inhibition of human ERG at 10 uM by fluorescence polarization assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
9. | ALA5035506 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
10. | ALA5035507 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
11. | ALA5035508 | A | Inhibition of CYP2C19 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
12. | ALA5035509 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
13. | ALA5035510 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
14. | ALA5035511 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining measured after 30 mins | Mus musculus | 2 | microsome format | Scientific Literature | ||
15. | ALA5035512 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining measured after 30 mins | Homo sapiens | 2 | microsome format | Scientific Literature | ||
16. | ALA5035513 | F | Antialzheimer activity in transgenic 5XFAD mouse model assessed as amyloid betaN3pE-40 levels in hippocampus at 10 mM administered every day for 4 weeks via brain infusion by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA5035514 | F | Antialzheimer activity in transgenic 5XFAD mouse model assessed as amyloid betaN3pE-42 levels in hippocampus at 10 mM administered every day for 4 weeks via brain infusion by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA5035515 | F | Antialzheimer activity in transgenic 5XFAD mouse model assessed as amyloid beta40 levels in hippocampus at 10 mM administered every day for 4 weeks via brain infusion by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA5035516 | F | Antialzheimer activity in transgenic 5XFAD mouse model assessed as amyloid beta42 levels in hippocampus at 10 mM administered every day for 4 weeks via brain infusion by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
20. | ALA5035517 | F | Antialzheimer activity against transgenic 5XFAD mouse assessed as reversal of behavioral effect by measuring total arm entries at 10 mM for 4 weeks via brain infusion by Y-maze test | Mus musculus | 1 | organism-based format | Scientific Literature |