# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5053357 | B | Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 15 mins followed by ATP addition and further incubated for 15 mins and measured after 40 mins by ADP-Glo reagent based assay | Homo sapiens | 172 | ALA5052846 | assay format | Patent Bioactivity Data | |
2. | ALA5224086 | B | Inhibition of recombinant His-tagged human KIF18A (1 to 467 residues) expressed in Trichoplusia ni insect cells assessed as inhibition of microtubule-stimulated ATPase activity preincubated for 30 mins followed by ATP addition and further incubated for 15 mins by ADP-Glo reagent based assay | Homo sapiens | 26 | ALA5223091 | cell-based format | Scientific Literature | |
3. | ALA5224090 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Mus musculus | 23 | ALA5223091 | microsome format | Scientific Literature | |
4. | ALA5224091 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance at 0.5 uM incubated upto 40 mins by LCMS analysis | Homo sapiens | 23 | ALA5223091 | microsome format | Scientific Literature | |
5. | ALA5224092 | F | Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay | Homo sapiens | 22 | ALA5223091 | cell-based format | Scientific Literature | |
6. | ALA5224093 | F | Antiproliferative activity against human OVCAR-3 cells by nuclear count assay | Homo sapiens | 22 | ALA5223091 | cell-based format | Scientific Literature |