# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5053067 | B | Inhibition of SERPINA3N in mouse N2a cells chronically infected with RML prion (ScN2a) assessed as reduction of PrPSc levels measured by western blot analysis | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
2. | ALA5053068 | B | Inhibition of SERPINA3N in mouse GT1 cells chronically infected with RML prion (ScGT1) assessed as reduction of PrPSc levels measured by western blot analysis | Mus musculus | 8 | cell-based format | Patent Bioactivity Data | ||
3. | ALA5053069 | B | Inhibition of SERPINA3N in mouse GT1 cells chronically infected with 22L prion strain (ScGT1 22L) assessed as reduction of PrPSc levels measured by western blot analysis | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
4. | ALA5149161 | B | Inhibition of SerpinA3n in mouse ScN2a cells infected with 22L prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometric analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
5. | ALA5149162 | B | Inhibition of SerpinA3n in mouse ScGT1 cells infected with RML prion assessed as reduction of PrPSc accumulation at 20 uM measured by Western blot based densitometric analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
6. | ALA5149166 | B | Inhibition of C-terminal His-tagged mouse recombinant SerpinA3n expressed in Escherichia coli BL21(DE3) pLysS cells assessed as inhibition of SerpinA3n-bovine alpha chymotrypsin complex formation incubated for 30 mins by Coomassie blue staining based SDS-PAGE analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
7. | ALA5149167 | B | Binding affinity to C-terminal His-tagged mouse recombinant SerpinA3n expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation constant by isothermal titration calorimetry method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
8. | ALA5149168 | B | Binding affinity to C-terminal His-tagged mouse recombinant SerpinA3n expressed in Escherichia coli BL21(DE3) pLysS cells assessed as dissociation constant at stoichiometry ratio of 1:1 by isothermal titration calorimetry method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
9. | ALA5149169 | B | Binding affinity to C-terminal His-tagged mouse recombinant SerpinA3n expressed in Escherichia coli BL21(DE3) pLysS cells in buffer assessed as dissociation constant by isothermal titration calorimetry method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
10. | ALA5149170 | B | Inhibition of SerpinA3n in mouse ScGT1 cells infected with 22L prion assessed as reduction of PrPSc accumulation at 20 uM by Western blot based densitometric analysis relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
11. | ALA5149171 | B | Inhibition of SerpinA3n in mouse ScN2a cells infected with RML prion assessed as reduction of PrPSc accumulation at 20 uM by Western blot based densitometric analysis relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
12. | ALA5149172 | B | Inhibition of SerpinA3n in mouse ScN2a cells infected with 22L prion assessed as reduction of PrPSc accumulation at 20 uM by Western blot based densitometric analysis relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
13. | ALA5149173 | B | Inhibition of SerpinA3n in mouse ScGT1 cells infected with RML prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometric analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
14. | ALA5149174 | B | Inhibition of SerpinA3n in mouse ScGT1 cells infected with 22L prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometric analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
15. | ALA5149175 | B | Inhibition of SerpinA3n in mouse ScN2a cells infected with RML prion assessed as reduction of PrPSc accumulation measured after 3 days by densitometric analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
16. | ALA5149176 | T | Cytotoxicity against mouse ScGT1 cells infected with RML prion assessed as lethal dose measured after 6 days | Mus musculus | 1 | cell-based format | Scientific Literature | ||
17. | ALA5149177 | T | Cytotoxicity against mouse ScGT1cells infected with 22L prion assessed as lethal dose measured after 6 days | Mus musculus | 1 | cell-based format | Scientific Literature | ||
18. | ALA5149178 | T | Cytotoxicity against mouse ScN2a cells infected with RML prion assessed as lethal dose measured after 6 days | Mus musculus | 1 | cell-based format | Scientific Literature | ||
19. | ALA5149179 | T | Cytotoxicity against mouse ScN2a cells infected with 22L prion assessed as lethal dose measured after 6 days | Mus musculus | 1 | cell-based format | Scientific Literature | ||
20. | ALA5149180 | F | Downregulation of PrPSc level in mouse ScGT1 cells infected with RML prion at 20 uM for 4 passages measured up to 1 month by Western blotting analysis | Mus musculus | 1 | cell-based format | Scientific Literature |