# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5057963 | B | Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-FRET assay | Homo sapiens | 28 | ALA5055684 | assay format | Scientific Literature | |
2. | ALA5057964 | P | Solubility of the compound in HEPES buffer incubated for 20 hrs by quantitative - 1H-NMR analysis | 18 | ALA5055684 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA5057966 | A | Permeability of the compound by PAMPA | 12 | ALA5055684 | assay format | Scientific Literature | ||
4. | ALA5057967 | B | Inhibition of human nanoLuc-tagged BCL6 expressed in HEK293T cells coexpressing HaloTag-SMRT using NanoBRET furimazine substrate incubated for 6 hrs by NanoBRET assay | Homo sapiens | 8 | ALA5055684 | cell-based format | Scientific Literature | |
5. | ALA5057968 | B | Binding affinity to human BCL6 BDB domain by SPR assay | Homo sapiens | 1 | ALA5055684 | single protein format | Scientific Literature | |
6. | ALA5057969 | F | Antiproliferative activity against BCL-6 positive human OCI-Ly1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo assay | Homo sapiens | 1 | ALA5055684 | cell-based format | Scientific Literature | |
7. | ALA5057970 | F | Antiproliferative activity against BCL-6 positive human SU-DHL-4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo assay | Homo sapiens | 1 | ALA5055684 | cell-based format | Scientific Literature | |
8. | ALA5057971 | F | Antiproliferative activity against BCL-6 positive human SU-DHL-6 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo assay | Homo sapiens | 1 | ALA5055684 | cell-based format | Scientific Literature | |
9. | ALA5057972 | F | Antiproliferative activity against BCL-6 low human OCILY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo assay | Homo sapiens | 1 | ALA5055684 | cell-based format | Scientific Literature | |
10. | ALA5057973 | F | Antiproliferative activity against BCL-6 low human MM.1S cells assessed as growth inhibition incubated for 14 days by CellTiter Glo assay | Homo sapiens | 1 | ALA5055684 | cell-based format | Scientific Literature | |
11. | ALA5057974 | T | Toxicity in BALB/c mouse at 1 mg/kg, iv or 5 mg/kg, po | Mus musculus | 1 | ALA5055684 | organism-based format | Scientific Literature | |
12. | ALA5057975 | A | Clearance in BALB/c mouse at 1 mg/kg, iv or 5 mg/kg, po | Mus musculus | 1 | ALA5055684 | organism-based format | Scientific Literature | |
13. | ALA5057976 | A | Oral bioavailability in BALB/c mouse at 5 mg/kg | Mus musculus | 1 | ALA5055684 | organism-based format | Scientific Literature | |
14. | ALA5057977 | A | Plasma concentration in BALB/c mouse assessed as unbound fraction at 1 mg/kg, iv or 5 mg/kg, po | Mus musculus | 1 | ALA5055684 | organism-based format | Scientific Literature | |
15. | ALA5057978 | B | Inhibition of BCOR peptide binding to human BCL6 expressed in Escherichia coli measured after 270 mins by BCOR ULight TR-FRET assay | Homo sapiens | 2 | ALA5055684 | assay format | Scientific Literature | |
16. | ALA5057979 | P | Lipophilicity, logD of the compound at pH 7.4 | 3 | ALA5055684 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA5136200 | P | Kinetic aqueous solubility of the compound in pH 7.4 in 1% DMSO/PBS buffer measured after 2 hrs by HPLC-UV analysis | 7 | ALA5131540 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA5136201 | B | Inhibition of human C-terminal nanoLuc-tagged BCL6 expressed in HEK293T cells co-expressing HaloTagged-SMRT using NanoBRET furimazine as substrate incubated for 6 hrs by NanoBRET assay | Homo sapiens | 12 | ALA5131540 | cell-based format | Scientific Literature | |
19. | ALA5136202 | B | Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate incubated for 2 hrs by TR-FRET assay | Homo sapiens | 24 | ALA5131540 | assay format | Scientific Literature | |
20. | ALA5136203 | F | Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay | Homo sapiens | 2 | ALA5131540 | cell-based format | Scientific Literature |