| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5038468 | F | Antiinflammatory activity in human THP-1 cells assessed as inhibition of LPS/nigericin-induced IL-1beta secretion in LPS stimulation followed by pretreatment for 40 min before induced with nigericin for 40 min measured by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5038469 | A | Cytotoxicity against human THP-1 cells assessed as reduction in cell viability at 0.05 to 6.4 uM measured after 90 mins by CCK8 assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA5038471 | F | Antiinflammatory activity in human THP-1 cells assessed as blockade of caspase 1 p20 in LPS stimulation followed by pretreatment for 40 min before induced with nigericin for 40 min measured by western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5038472 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated human THP-1 cells assessed as blockade of pro caspase 1 p20 in LPS stimulation followed by pretreatment for 40 min before induced with nigericin for 40 min measured by western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 5. | ALA5038473 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated human THP-1 cells assessed as LPS-induced IL-1beta secretion in LPS stimulation followed by pretreatment for 40 min before induced with nigericin for 40 min measured by western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 6. | ALA5038474 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated human THP-1 cells assessed as reduction in pyroptosis in LPS stimulation for 3 hrs followed by pretreatment for 40 min before induced with nigericin for 40 min by propidium iodide staining based inverted microscopic assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA5038475 | B | Inhibition of NLRC4 inflammasome activation in LPS-induced human THP-1 cells at 1 uM for 40 mins followed by flagellin stimulation for 6 h by ELISA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 8. | ALA5038476 | B | Inhibition of AIM2 inflammasome activation in LPS-induced human THP-1 cells at 1 uM for 40 mins followed by flagellin stimulation for 6 h by ELISA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 9. | ALA5038477 | B | Inhibition of NLRC4 inflammasome activation in LPS-induced human THP-1 cells at 3 to 5uM for 40 mins followed by flagellin stimulation for 6 h by ELISA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA5038478 | B | Inhibition of AIM2 inflammasome activation in LPS-induced human THP-1 cells at 3 to 5uM for 40 mins followed by flagellin stimulation for 6 h by ELISA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA5038479 | F | Effect on NLRP3 expression in LPS-stimulated human THP-1 cells at 1 uM preincubated for 40 mins followed by LPS stimulation and measured after 3 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 12. | ALA5038480 | F | Effect on IL-1beta expression in LPS-stimulated human THP-1 cells at 1 uM preincubated for 40 mins followed by LPS stimulation and measured after 3 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA5038481 | F | Effect on TNFalpha expression in LPS-stimulated human THP-1 cells at 1 uM preincubated for 40 mins followed by LPS addition and measured after 3 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA5038482 | F | Effect on NLRP3 expression in LPS-stimulated human THP-1 cells preincubated for 40 mins followed by LPS addition and measured after 3 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 15. | ALA5038483 | F | Effect on IL-1beta expression in LPS-stimulated human THP-1 cells preincubated for 40 mins followed by LPS addition and measured after 3 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 16. | ALA5038484 | F | Effect on TNFalpha expression in LPS-stimulated human THP-1 cells preincubated for 40 mins followed by LPS addition and measured after 3 hrs by Western blot analysis | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 17. | ALA5038485 | F | Effect on ASC oligomerization in LPS/nigericin stimulated human THP-1 cells assessed as ASC specks in LPS stimulation for 3 hrs followed by pretreatment for 40 min before induced with nigericin for 40 min by ASC and DAPI staining based immunofluorescent microscopy | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 18. | ALA5038486 | B | Binding affinity to NLRP3 in LPS stimulated human THP-1cells assessed as prevention of pronase-mediated protein degradation at 0.01 to 1mM incubated 50 mins before pronase treatment by label-free DARTS assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 19. | ALA5038487 | B | Inhibition of NLRP3 in human THP-1cells assessed as increase in thermal stability at 100 uM by cellular thermal shift assay | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 20. | ALA5038488 | B | Inhibition of NLRP3 in human THP-1cells assessed as increase in thermal stability at 0.5 to 5 uM at 57 deg C measured by cellular thermal shift assay | Homo sapiens | 1 | tissue-based format | Scientific Literature |
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