| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5043484 | B | Protac activity at human CDK12/CycK in human Bel-7402 cells assessed as degradation of CDK12 at 3 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA5043485 | B | Inhibition of human CDK12 (696 to 1082 residues) /cyclinK (1 to 300 residues) using ac-YSPTSPpSYSPTSFpS-YSPTSPpSY-[PEG2]-RR-amid peptide as substrate in presence of ATP measured after 2 hrs by ADP-Glo kinase assay | Homo sapiens | 7 | protein complex format | Scientific Literature | ||
| 3. | ALA5043486 | B | Protac activity at human CDK12/CycK in human MDA-MB-231 cells assessed as degradation of CDK12 at 3 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA5043487 | B | Protac activity at human CDK12/CycK in human Bel-7402 cells assessed as degradation of CDK12 measured after 24 hrs by Western blotting assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA5043488 | B | Protac activity at human CDK12/CycK in human Bel-7402 cells assessed as degradation of CycK measured after 24 hrs by Western blotting assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA5043489 | B | Protac activity at human CDK12/CycK in human MDA-MB-231 cells assessed as degradation of CDK12 measured after 24 hrs by Western blotting assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA5043490 | B | Protac activity at human CDK12/CycK in human MDA-MB-231 cells assessed as degradation of CycK measured after 24 hrs by Western blotting assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA5043491 | B | Protac activity at human CDK12/CycK in human Bel-7402 cells assessed as degradation of CDK7 up to 30 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5043492 | B | Protac activity at human CDK12/CycK in human MDA-MB-231 cells assessed as degradation of CDK7 up to 30 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA5043493 | B | Protac activity at human CDK12/CycK in human Bel-7402 cells assessed as degradation of CDK9 upto 30 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA5043494 | B | Protac activity at human CDK12/CycK in human Bel-7402 cells assessed as RNAP2 CTD Ser2 phosphorylation level at 0.1 to 30 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA5043495 | B | Protac activity at human CDK12/CycK in human MDA-MB-231 cells assessed as degradation of CDK9 up to 30 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA5043496 | B | Protac activity at human CDK12/CycK in human MDA-MB-231 cells assessed as RNAP2 CTD Ser2 phosphorylation level at 0.1 to 30 uM measured after 24 hrs by Western blotting assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 14. | ALA5043497 | B | Protac activity at human CDK12/CycK in human Bel-7402 (CRBN/KO) cells assessed as degradation of CDK12 measured after 24 hrs by Western blotting assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA5043498 | B | Protac activity at human CDK12/CycK in human MDA-MB-231(CRBN/KO) cells assessed as degradation of CDK12 measured after 24 hrs by Western blotting assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA5043501 | B | Protac activity at human CDK12/CycK in human Bel-7402 cells assessed as downregulation of ATM measured after 6 hrs by RT-qPCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA5043502 | B | Protac activity at human CDK12/CycK in human MDA-MB-231 cells assessed as downregulation of ATM measured after 6 hrs by RT-qPCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA5043503 | B | Protac activity at human CDK12/CycK in human Bel-7402 cells assessed as downregulation of ATR measured after 6 hrs by RT-qPCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5043504 | B | Protac activity at human CDK12/CycK in human MDA-MB-231 cells assessed as downregulation of ATR measured after 6 hrs by RT-qPCR method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA5043505 | F | Synergistic antiproliferative activity against human MDA-MB-231 cells in presence of 1 uM of Olaparib at 1 uM for 10 days by SRB staining based clone formation assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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