# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5043200 | A | Drugmetabolism in mouse liver microsomes assessed as metabolite formation | Mus musculus | 1 | ALA5042486 | microsome format | Scientific Literature | |
2. | ALA5043201 | F | Inhibition of FcgammaRIII mediated TNF alpha secretion in cross-linked anti-CD16 stimulated human monocyte | Homo sapiens | 1 | ALA5042486 | cell-based format | Scientific Literature | |
3. | ALA5043203 | B | Inhibition of human BTK using fluorescein-labeled polyGAT peptide as substrate incubated for 30 mins by FRET assay | Homo sapiens | 40 | ALA5042486 | single protein format | Scientific Literature | |
4. | ALA5043204 | B | Inhibition of BTK phosphorylation in human whole blood assessed as reduction in BTK phosphorylation incubated for 30 mins | Homo sapiens | 17 | ALA5042486 | tissue-based format | Scientific Literature | |
5. | ALA5043205 | B | Inhibition of CD69 in human whole blood preincubated for 30 mins followed by anti-human IgD stimulation and measured after 18 to 22 hrs by flow cytometry | Homo sapiens | 27 | ALA5042486 | tissue-based format | Scientific Literature | |
6. | ALA5043206 | P | Kinetic aqueous solubility of the compound in pH 6.8 | 16 | ALA5042486 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA5043208 | A | Clearance in rat liver microsomes assessed as hepatic blood flow | Rattus norvegicus | 13 | ALA5042486 | microsome format | Scientific Literature | |
8. | ALA5043209 | A | Clearance in human liver microsomes assessed as hepatic blood flow | Homo sapiens | 13 | ALA5042486 | microsome format | Scientific Literature | |
9. | ALA5043210 | A | Protein binding in human plasma assessed as unbound fraction at 2 uM by rapid equilibrium dialysis method | Homo sapiens | 13 | ALA5042486 | cell-free format | Scientific Literature | |
10. | ALA5043211 | P | Kinetic solubility of the compound at pH 1.5 by shake flask method | 13 | ALA5042486 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA5043213 | P | Lipophilicity, logD of the compound at pH 7.6 by shake flask assay | 13 | ALA5042486 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA5043215 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 3 | ALA5042486 | organism-based format | Scientific Literature | |
13. | ALA5043216 | A | Clearance in Beagle dog at 1 mg/kg, iv | Canis lupus familiaris | 3 | ALA5042486 | organism-based format | Scientific Literature | |
14. | ALA5043217 | A | Clearance in Sprague-Dawley rat assessed as hepatic blood flow at 1 mg/kg, iv | Rattus norvegicus | 3 | ALA5042486 | organism-based format | Scientific Literature | |
15. | ALA5043218 | A | Clearance in Beagle dog assessed as hepatic blood flow at 1 mg/kg, iv | Canis lupus familiaris | 3 | ALA5042486 | organism-based format | Scientific Literature | |
16. | ALA5043224 | A | Cmax in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 3 | ALA5042486 | organism-based format | Scientific Literature | |
17. | ALA5043225 | A | Cmax in Beagle dog at 5 mg/kg, po | Canis lupus familiaris | 3 | ALA5042486 | organism-based format | Scientific Literature | |
18. | ALA5043226 | A | Oral bioavailability in Sprague-Dawley rat at 5 mg/kg | Rattus norvegicus | 3 | ALA5042486 | organism-based format | Scientific Literature | |
19. | ALA5043227 | A | Oral bioavailability in Beagle dog at 5 mg/kg | Canis lupus familiaris | 3 | ALA5042486 | organism-based format | Scientific Literature | |
20. | ALA5043231 | B | Binding affinity to wild-type human full length BTK (M1 to S659 residues) expressed in mammalian expression system by Kinomescan method | Homo sapiens | 4 | ALA5042486 | assay format | Scientific Literature |