# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5045598 | Binding | Inhibition of sigma 2 receptor (unknown origin) assessed as binding constant | Homo sapiens | 17 | ALA5042543 | single protein format | Scientific Literature | |
2. | ALA5045600 | Physicochemical | Aqueous solubility of the compound at pH 4 | 32 | ALA5042543 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA5045601 | Binding | Inhibition of fluorescent antagonist binding to human P2Y14R expressed in CHO cells preincubated for 30 mins followed by 6-amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy 6-(4-(trifluoromethyl)phenyl)naphthalen-1-yl)phenyl)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)phenyl)-3-iminio-5-sulfo-3H-xanthene-4-sulfonate addition and measured after 30 mins by BD FACSCalibur flow cytometry analysis | Homo sapiens | 40 | ALA5042543 | cell-based format | Scientific Literature | |
4. | ALA5045602 | Physicochemical | Aqueous solubility of the compound at pH 7.4 | 32 | ALA5042543 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA5045603 | Physicochemical | Distribution coefficient, logD of compound at pH 7.4 by HPLC analysis | 33 | ALA5042543 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA5045604 | Binding | Inhibition of fluorescent antagonist binding to mouse P2Y14R expressed in HEK293 cells preincubated for 30 mins followed by addition of 6-amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)naphthalen-1-yl)phenyl)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)phenyl)-3-iminio-5-sulfo-3H-xanthene-4-sulfonate incubated for 30 mins by BD FACSCalibur flow cytometry analysis | Mus musculus | 10 | ALA5042543 | cell-based format | Scientific Literature | |
7. | ALA5045613 | Binding | Inhibition of adrenergic alpha 2B receptor (unknown origin) assessed as binding constant | Homo sapiens | 7 | ALA5042543 | single protein format | Scientific Literature | |
8. | ALA5045615 | ADME | Stability of the compound in simulated intestinal fluid assessed as parent compound remaining at 120 mins | 2 | ALA5042543 | assay format | Scientific Literature | ||
9. | ALA5045616 | ADME | Stability of the compound in simulated gastric fluid assessed as parent compound remaining at 120 mins by NMR analysis | 2 | ALA5042543 | assay format | Scientific Literature | ||
10. | ALA5045617 | ADME | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 2 | ALA5042543 | single protein format | Scientific Literature | |
11. | ALA5045618 | ADME | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | ALA5042543 | single protein format | Scientific Literature | |
12. | ALA5045619 | ADME | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 2 | ALA5042543 | single protein format | Scientific Literature | |
13. | ALA5045620 | ADME | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | ALA5042543 | single protein format | Scientific Literature | |
14. | ALA5045621 | ADME | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA5042543 | single protein format | Scientific Literature | |
15. | ALA5045622 | ADME | Stability in rat plasma assessed as compound remaining after 120 mins | Rattus norvegicus | 2 | ALA5042543 | cell-free format | Scientific Literature | |
16. | ALA5045623 | ADME | Stability in mouse plasma assessed as compound remaining after 120 mins | Mus musculus | 2 | ALA5042543 | cell-free format | Scientific Literature | |
17. | ALA5045624 | ADME | Stability in mouse liver microsomes assessed as half life | Mus musculus | 2 | ALA5042543 | microsome format | Scientific Literature | |
18. | ALA5045625 | ADME | Stability in rat liver microsomes assessed as half life | Rattus norvegicus | 2 | ALA5042543 | microsome format | Scientific Literature | |
19. | ALA5045626 | ADME | Stability in human liver microsomes assessed as half life | Homo sapiens | 2 | ALA5042543 | microsome format | Scientific Literature | |
20. | ALA5045627 | Toxicity | Inhibition of hERG channel by patch clamp assay | Homo sapiens | 2 | ALA5042543 | assay format | Scientific Literature |