| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5047185 | Functional | Antitumor activity against human RPMI-8226 cells xenografted in BALB/c nude mouse assessed as inhibition of tumor growth at 100 mg/kg/day, po measured after 23 days | Mus musculus | 1 | ALA5046235 | organism-based format | Scientific Literature | |
| 2. | ALA5047186 | ADME | Cmax in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5046235 | organism-based format | Scientific Literature | |
| 3. | ALA5047187 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5046235 | organism-based format | Scientific Literature | |
| 4. | ALA5047188 | Toxicity | Acute toxicity in ICR mouse assessed as effect on spleen at 10000 mg/kg, po administered once daily and measured every 2 days by H and E staining method | Mus musculus | 1 | ALA5046235 | organism-based format | Scientific Literature | |
| 5. | ALA5047189 | Toxicity | Acute toxicity in ICR mouse assessed as effect on liver at 10000 mg/kg, po administered once daily and measured every 2 days by H and E staining method | Mus musculus | 1 | ALA5046235 | organism-based format | Scientific Literature | |
| 6. | ALA5047190 | ADME | Clearance in Sprague-Dawley rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5046235 | organism-based format | Scientific Literature | |
| 7. | ALA5047191 | Functional | Antitumor activity against human RPMI-8226 cells xenografted in BALB/c nude mouse assessed as inhibition of tumor growth at 200 mg/kg/day, po measured after 23 days | Mus musculus | 1 | ALA5046235 | organism-based format | Scientific Literature | |
| 8. | ALA5047192 | Binding | Inhibition of CDK6/Cyclin D1 (unknown origin) using ULight-MBP peptide substrate in presence of ATP by TR-FRET assay | Homo sapiens | 45 | ALA5046235 | protein complex format | Scientific Literature | |
| 9. | ALA5047193 | Binding | Inhibition of CDK1/Cyclin B (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 10. | ALA5047194 | Binding | Inhibition of CDK2/Cyclin A (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 11. | ALA5047195 | Binding | Inhibition of CDK3/Cyclin E (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 12. | ALA5047196 | Binding | Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 13. | ALA5047197 | Binding | Inhibition of CDK5/P25 (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 14. | ALA5047198 | Binding | Inhibition of CDK6/Cyclin D1 (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 15. | ALA5047199 | Binding | Inhibition of CDK7/Cyclin H (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 16. | ALA5047200 | Binding | Inhibition of CDK9/Cyclin T1 (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 17. | ALA5047201 | Binding | Inhibition of CDK14/Cyclin Y (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 18. | ALA5047202 | Binding | Inhibition of CDK16/Cyclin Y (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 19. | ALA5047203 | Binding | Inhibition of CDK17/Cyclin Y (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature | |
| 20. | ALA5047204 | Binding | Inhibition of CDK18/Cyclin Y (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay | Homo sapiens | 1 | ALA5046235 | protein complex format | Scientific Literature |
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