# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5041208 | B | Inhibition of human Nav1.7 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -95 mV by Qube-automated patch clamp assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
2. | ALA5041209 | B | Inhibition of human Nav1.4 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -95 mV by whole-cell Qube-automated patch clamp assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
3. | ALA5041210 | B | Inhibition of human Nav1.6 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -85 mV by whole-cell Qube-automated patch clamp assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
4. | ALA5041211 | B | Inhibition of human Nav1.7 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -95 mV by whole-cell QPatch HT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
5. | ALA5041212 | B | Inhibition of rat Nav1.7 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -90 mV by whole-cell QPatch HT assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
6. | ALA5041213 | B | Inhibition of human Nav1.2 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -95 mV by Qube-automated patch clamp assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
7. | ALA5041214 | A | Inhibition of human Cav1.2 stably expressed in HEK293 cells incubated for 30 mins in dark by Fluo-4 AM dye based FLIPR assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
8. | ALA5041215 | T | Inhibition of human ERG by PatchXpress assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
9. | ALA5041216 | T | Inhibition of human Nav1.5 by PatchXpress assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
10. | ALA5041217 | F | Inhibition of mast cell degranulation in Wistar Han rat peritoneal lavage mast cells assessed as inhibition histamine release by measuring lowest concentration at which histamine release observed measured after 30 mins | Rattus norvegicus | 24 | cell-based format | Scientific Literature | ||
11. | ALA5041218 | F | Effect on mast cell degranulation in Wistar Han rat peritoneal lavage mast cells assessed as increase in histamine level by measuring histamine Cmax in plasma at 0.3 mg/kg, iv administered as bolus dose measured up to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
12. | ALA5041219 | F | Effect on mast cell degranulation in Wistar Han rat peritoneal lavage mast cells assessed as fold increase in histamine level by measuring histamine Cmax in plasma at 0.3 mg/kg, iv administered as bolus dose measured up to 24 hrs by LC/MS/MS analysis relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
13. | ALA5041222 | F | Antinociceptive activity against Sprague-Dawley rat model of thermal stimuli induced nociception assessed as increase in tail withdrawal latency administered subcutaneously as single dose measured up to 24 hrs by tail flick test | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
14. | ALA5041223 | F | Antinociceptive activity against Sprague-Dawley rat model of thermal stimuli induced nociception assessed as concentration required for maximal tail flick withdrawal latency administered subcutaneously as single dose measured up to 24 hrs by tail flick test | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
15. | ALA5041224 | F | Ratio of IC50 for inhibition of rat Nav1.7 stably expressed in cells to EC50 for antinociceptive activity against Sprague-Dawley rat model of thermal stimuli induced nociception assessed as concentration required for maximal tail flick withdrawal latency | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
16. | ALA5041227 | A | Half life in Wistar Han rat at 0.3 mg/kg, iv measured upto 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature |