# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5034161 | F | Positive allosteric modulator activity at human mGlu2 receptor expressed in rat Chem-1 cells assessed as cytosolic Ca2+ ion concentration measured after 30 mins by fluorometric analysis | Homo sapiens | 26 | cell-based format | Scientific Literature | ||
2. | ALA5034162 | A | Intrinsic clearance in human liver microsomes at 2.5 uM | Homo sapiens | 20 | microsome format | Scientific Literature | ||
3. | ALA5034163 | A | Intrinsic clearance in Wistar rat liver microsomes at 2.5 uM | Rattus norvegicus | 20 | microsome format | Scientific Literature | ||
4. | ALA5034164 | B | Inhibition of human ERG by patch clamp electrophysiology assay | Homo sapiens | 20 | assay format | Scientific Literature | ||
5. | ALA5034165 | P | Lipophilicity, log D of compound at pH 7.4 | 2 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA5034166 | P | Aqueous solubility of compound at pH 7.4 | 2 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA5034167 | A | Plasma protein binding in mouse | Mus musculus | 2 | cell-free format | Scientific Literature | ||
8. | ALA5034168 | A | Plasma protein binding in rat | Rattus norvegicus | 2 | cell-free format | Scientific Literature | ||
9. | ALA5034169 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
10. | ALA5034170 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
11. | ALA5034171 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
12. | ALA5034172 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
13. | ALA5034173 | A | Clearance in Wistar rat at 3 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
14. | ALA5034174 | A | Volume of distribution in Wistar rats at 3 mg/kg,po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
15. | ALA5034175 | A | Half life in Wistar rat at 3 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
16. | ALA5034176 | A | Half life in Wistar rat at10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
17. | ALA5034177 | A | Tmax in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
18. | ALA5034178 | A | AUC (0 to 2 hours ) in Wistar rat at 3 mg/kg, iv | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
19. | ALA5034179 | A | AUC (0 to 5 hours ) in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
20. | ALA5034180 | A | Cmax in Wistar rat at 10 mg/kg, po | Rattus norvegicus | 1 | organism-based format | Scientific Literature |