| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5043155 | F | Antitumour activity against human HCC70 cells xenografted in BALB/c mouse assessed as tumour growth inhibition at 4 mg/kg, po bid for 21 days measured after 7 days post treatment by vernier caliper method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA5043156 | A | Oral bioavailability in CD-1 mouse 5 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 12 | organism-based format | Scientific Literature | ||
| 3. | ALA5043157 | A | Unbound clearance in CD-1 mouse at 1 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 14 | organism-based format | Scientific Literature | ||
| 4. | ALA5043158 | A | Apparent permeability across apical to basolateral side in MDCK cells | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 5. | ALA5043159 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 15 | microsome format | Scientific Literature | ||
| 6. | ALA5043160 | P | Lipophilicity, log D of compound | 15 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA5043162 | B | Inhibition of CDK2/cyclin E1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | protein complex format | Scientific Literature | ||
| 8. | ALA5043163 | F | Antiproliferative activity against human HCC70 cells incubated for 72 hrs by Celltiter-glo assay | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 9. | ALA5043164 | B | Binding affinity to full length CDK7 (1 to 346 residues) /N-terminal TEV cleavable 6His tagged full length cyclinH (1 to 323 residues) (unknown origin) expressed in baculovirus infected Sf9 cells by Surface plasmon resonance assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 10. | ALA5043165 | B | Inhibition of CDK9/cyclin T1 (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | protein complex format | Scientific Literature | ||
| 11. | ALA5043166 | B | Inhibition of CDK12/cyclin K (unknown origin) using 5-FAM-labeled peptide as substrate in presence of ATP by mobility shift assay | Homo sapiens | 15 | protein complex format | Scientific Literature | ||
| 12. | ALA5043168 | F | Antitumour activity against human HCC70 cells xenografted in po dosed BALB/c mouse assessed as tumour growth inhibition administered twice daily for 21 days measured after 7 days post treatment by vernier caliper method | Mus musculus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!