| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5050272 | A | Bioavailability in Fresian-Holstein cattle at 5 mg/kg, IM measured upto 120 hrs | Bos taurus | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 2. | ALA5050273 | A | Tmax in Fresian-Holstein cattle at 5 mg/kg, IM measured upto 120 hrs | Bos taurus | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 3. | ALA5050275 | P | Kinetic aqueous solubility of the compound in PBS at pH 7.4 for 24 hrs by UHPLC analysis | 10 | ALA5046314 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA5050276 | F | Antitrypanosomal activity against bloodstream Trypanosoma brucei brucei assessed as parasite growth inhibition incubated for 3 days by resazurin dye based fluorescence analysis | Trypanosoma brucei brucei | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 5. | ALA5050277 | F | Antitrypanosomal activity against bloodstream Trypanosoma congolense IL3000 assessed as parasite growth inhibition incubated for 69 hrs by resazurin dye based fluorescence analysis | Trypanosoma congolense | 8 | ALA5046314 | organism-based format | Scientific Literature | |
| 6. | ALA5050278 | F | Antitrypanosomal activity against bloodstream Trypanosoma vivax STIB 719/ ILRAD 560 assessed as parasite growth inhibition incubated for 45 hrs by resazurin dye based fluorescence analysis | Trypanosoma vivax | 8 | ALA5046314 | assay format | Scientific Literature | |
| 7. | ALA5050279 | A | Metabolic stability in CD1 mouse liver microsomes assessed as intrinsic clearance at 0.5 uM in presence of NADPH measured up to 30 mins by UPLC-MS/MS analysis | Mus musculus | 1 | ALA5046314 | microsome format | Scientific Literature | |
| 8. | ALA5050280 | A | Metabolic stability in cryopreserved mouse hepatocytes assessed as intrinsic clearance at 1 uM measured up to 120 mins by UPLC-MS/MS analysis | Mus musculus | 1 | ALA5046314 | cell-based format | Scientific Literature | |
| 9. | ALA5050281 | A | Metabolic stability in bovine liver microsomes assessed as intrinsic clearance at 0.5 uM measured up to 30 mins by UPLC-MS/MS analysis | Bos taurus | 11 | ALA5046314 | microsome format | Scientific Literature | |
| 10. | ALA5050282 | A | Metabolic stability in bovine hepatocytes assessed as intrinsic clearance at 1 uM measured up to 120 mins by UPLC-MS/MS analysis | Bos taurus | 1 | ALA5046314 | cell-based format | Scientific Literature | |
| 11. | ALA5050283 | A | Protein binding in NMRI mouse plasma assessed as unbound fraction at 10 microg/ml measured after 5 hrs by UPLC-MS/MS based equilibrium dialysis method | Mus musculus | 1 | ALA5046314 | cell-free format | Scientific Literature | |
| 12. | ALA5050284 | T | Toxicity in po dosed mouse assessed as maximum tolerated dose | Mus musculus | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 13. | ALA5050285 | A | Bioavailability in NMRI mouse at 10 mg/kg, sc measured at 8 hrs post dose | Mus musculus | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 14. | ALA5050286 | A | Half life in NMRI mouse at 10 mg/kg, sc measured at 8 hrs post dose | Mus musculus | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 15. | ALA5050287 | F | Antitrypanosomal activity against bloodstream Trypanosoma brucei brucei infected in NMRI mouse assessed as parasite growth inhibition at 3 mg/kg, po BID for 4 days | Trypanosoma brucei brucei | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 16. | ALA5050288 | F | Antitrypanosomal activity against bloodstream Trypanosoma congolense IL3000 infected in NMRI mouse assessed as reduction in parasitemia at 10 mg/kg, sc BID for 4 days and measured twice a week for 21 days | Trypanosoma congolense | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 17. | ALA5050289 | F | Antitrypanosomal activity against bloodstream Trypanosoma congolense IL3000 infected in NMRI mouse assessed as reduction in parasitemia at 50 mg/kg, sc administered as single dose for 4 days and measured twice a week for 21 days | Trypanosoma congolense | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 18. | ALA5050290 | F | Antitrypanosomal activity against bloodstream Trypanosoma vivax STIB 719/ ILRAD 560 infected in NMRI mouse assessed as reduction in parasitemia at 3 mg/kg, sc BID for 4 days and measured twice a week for 21 days | Trypanosoma vivax | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 19. | ALA5050291 | F | Antitrypanosomal activity against bloodstream Trypanosoma vivax STIB 719/ ILRAD 560 infected in NMRI mouse assessed as reduction in parasitemia at 10 mg/kg, sc BID for 4 days and measured twice a week for 21 days | Trypanosoma vivax | 1 | ALA5046314 | organism-based format | Scientific Literature | |
| 20. | ALA5050292 | F | Antitrypanosomal activity against bloodstream Trypanosoma vivax STIB 719/ ILRAD 560 infected in NMRI mouse assessed as reduction in parasitemia at 30 mg/kg, sc administered as single dose and measured twice a week for 21 days | Trypanosoma vivax | 1 | ALA5046314 | organism-based format | Scientific Literature |
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