| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5045339 | F | Negative allosteric modulation activity at human recombinant mGlur2 expressed in CHO cells in presence of cAMP by chemiluminescence based assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA5045340 | F | Negative allosteric modulation activity at human recombinant mGlur2 expressed in HEK293T cells assessed as Gi/o-protein induced changes in intracellular cAMP level upto 300 nM in presence of isoproterenol by Glosensor assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA5045341 | F | Agonist activity at human recombinant mGlur2 expressed in tetracycline induced HEK293T cells assessed as Gi/o-protein induced changes in intracellular cAMP level in presence of isoproterenol by Glosensor assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA5045342 | F | Antagonist activity at human recombinant mGlur2 expressed in HEK293T cells assessed as protein induced changes in intracellular cAMP at 100 uM by Glosensor assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA5045343 | B | Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 6. | ALA5045344 | F | Negative allosteric modulation activity at human recombinant mGlur2 at 3 nM by cAMP Glosensor assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA5045346 | P | Lipophilicity, LogD at pH 7.4 of the compound by shake flask method | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA5045347 | A | Stability of the compound in rat plasma measured at 60 min | Rattus norvegicus | 2 | cell-free format | Scientific Literature | ||
| 9. | ALA5045348 | A | Stability of the compound in rat liver microsome measured at 60 min | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
| 10. | ALA5045349 | B | Substrate activity at human recombinant Pgp in cell membrane fraction assessed as stimulation of ATPase activity at 100 uM in presence of MgATP preincubated for 40 min measured after 20 min by Pgp-Glo assay | Homo sapiens | 2 | cell membrane format | Scientific Literature |
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