# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5033516 | Binding | Binding affinity to eGFP-fused human TEAD2 (217 to 447 residues) expressed in CHO-K1 cells by microscale thermophoresis analysis | Homo sapiens | 3 | ALA5032518 | cell-based format | Scientific Literature | |
2. | ALA5033517 | Binding | Inhibition of TEAD (unknown origin) transfected in HEK293T cells assessed as inhibition of TEAD transcriptional activity at 10 uM measured after 16 hrs by luciferase reporter gene assay | Homo sapiens | 8 | ALA5032518 | cell-based format | Scientific Literature | |
3. | ALA5033518 | Binding | Inhibition of TEAD (unknown origin) transfected in HEK293T cells assessed as inhibition of TEAD transcriptional activity measured after 16 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
4. | ALA5033519 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human MDA-MB-231 cells assessed as reduction in AXL protein expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
5. | ALA5033520 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human MDA-MB-231 cells assessed as reduction in CTGF protein expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
6. | ALA5033521 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human MDA-MB-231 cells assessed as reduction in Cyr61 protein expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
7. | ALA5033522 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human MDA-MB-231 cells assessed as reduction in Survivin protein expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
8. | ALA5033523 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human MDA-MB-231 cells assessed as reduction in AXL mRNA expression at 10 uM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
9. | ALA5033524 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human MDA-MB-231 cells assessed as reduction in CTGF mRNA expression at 10 uM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
10. | ALA5033525 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human MDA-MB-231 cells assessed as reduction in Cyr61 mRNA expression at 10 uM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
11. | ALA5033526 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell proliferation at 5 uM measured after 48 hrs by IncuCyte live-cell imaging assay | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
12. | ALA5033527 | Functional | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell proliferation at 10 uM measured after 48 hrs by IncuCyte live-cell imaging assay | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
13. | ALA5033533 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human HeLa cells assessed as reduction in AXL protein expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
14. | ALA5033534 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human HeLa cells assessed as reduction in CTGF protein expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
15. | ALA5033535 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human HeLa cells assessed as reduction in Cyr61 protein expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
16. | ALA5033536 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human HeLa cells assessed as reduction in Survivin protein expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
17. | ALA5033537 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human HeLa cells assessed as reduction in AXL mRNA expression at 10 uM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
18. | ALA5033538 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human HeLa cells assessed as reduction in CTGF mRNA expression at 10 uM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
19. | ALA5033539 | Binding | Inhibition of YAP/TAZ-TEAD interaction in human HeLa cells assessed as reduction in Cyr61 mRNA expression at 10 uM measured after 24 hrs by qRT-PCR analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature | |
20. | ALA5033540 | Functional | Effect on AXL protein expression in human SH-SY5Y cells lacking YAP/TAZ expression at 10 uM measured after 48 hrs by western blot analysis | Homo sapiens | 1 | ALA5032518 | cell-based format | Scientific Literature |