# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5050105 | Binding | PROTAC activity at CRBN/JAK2 in human MHHCALL4 cells assessed as protein degradation at 100 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 12 | ALA5046306 | cell-based format | Scientific Literature | |
2. | ALA5050106 | Binding | PROTAC activity at CRBN/JAK3 in human MHHCALL4 cells assessed as protein degradation at 100 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 10 | ALA5046306 | cell-based format | Scientific Literature | |
3. | ALA5050107 | Binding | PROTAC activity at CRBN/GSPT1 in human MHHCALL4 cells assessed as protein degradation at 100 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 12 | ALA5046306 | cell-based format | Scientific Literature | |
4. | ALA5050108 | Binding | Binding affinity to CRBN (unknown origin) measured by Fluorescent Polarization assay | Homo sapiens | 12 | ALA5046306 | single protein format | Scientific Literature | |
5. | ALA5050109 | Binding | PROTAC activity at CRBN/JAK2 in human MHHCALL4 cells assessed as protein degradation measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
6. | ALA5050110 | Functional | Cytotoxicity against human MHHCALL4 cells assessed as reduction in cell viability measured after 3 days by alamar blue viability assay | Homo sapiens | 3 | ALA5046306 | cell-based format | Scientific Literature | |
7. | ALA5050111 | Functional | Cytotoxicity against human CRBN knockdown MHHCALL4 cells assessed as reduction in cell viability measured after 3 days by alamar blue viability assay | Homo sapiens | 3 | ALA5046306 | cell-based format | Scientific Literature | |
8. | ALA5050112 | Binding | PROTAC activity at CRBN/JAK2 in human KOPN-49 cells assessed as protein degradation measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
9. | ALA5050113 | Binding | PROTAC activity at CRBN/JAK2 in human MHHCALL4 cells assessed as maximal protein degradation at 1 to 9000 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
10. | ALA5050114 | Binding | PROTAC activity at CRBN/JAK3 in human MHHCALL4 cells assessed as maximal protein degradation at 1 to 9000 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
11. | ALA5050115 | Binding | PROTAC activity at CRBN/JAK2 in human MHHCALL4 cells assessed as protein degradation at 100 nM after 16 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
12. | ALA5050116 | Binding | PROTAC activity at CRBN/JAK1 in human MHHCALL4 cells assessed as protein degradation at 1 to 9000 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
13. | ALA5050117 | Binding | PROTAC activity at CRBN/TYK2 in human MHHCALL4 cells assessed as protein degradation at 1 to 9000 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
14. | ALA5050118 | Binding | Degradation of JAK2 in human CRBN knockdown MHHCALL4 cells assessed as protein degradation at 1 to 9000 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
15. | ALA5050119 | Binding | PROTAC activity at CRBN/JAK1 in human KOPN-49 cells assessed as protein degradation at 1 to 9000 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
16. | ALA5050120 | Binding | PROTAC activity at CRBN/TYK2 in human KOPN-49 cells assessed as protein degradation at 1 to 9000 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
17. | ALA5050121 | Binding | Binding affinity to JAK2 (unknown origin) | Homo sapiens | 2 | ALA5046306 | single protein format | Scientific Literature | |
18. | ALA5050122 | Binding | PROTAC activity at CRBN/JAK2 in human CD45(+/+) leukemia cell derived from PDX-SJBALL020589 assessed as protein degradation measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
19. | ALA5050123 | Binding | PROTAC activity at CRBN/JAK3 in human CD45(+/+) leukemia cell derived from PDX-SJBALL020589 assessed as protein degradation measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature | |
20. | ALA5050124 | Binding | PROTAC activity at CRBN/JAK2 in human CD45(+/+) leukemia cell derived from PDX-SJBALL020589 assessed as maximal protein degradation at 1 to 9000 nM measured after 24 hrs by immunoblot analysis | Homo sapiens | 1 | ALA5046306 | cell-based format | Scientific Literature |