# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3579956 | Binding | Inhibition of human placental HexA using pNPGlcNAc substrate | Homo sapiens | 17 | ALA3576868 | assay format | Scientific Literature | |
2. | ALA3579957 | Binding | Chaperoning efficacy at HexA alpha G269S mutant in ATSD patient fibroblasts assessed as maximum increase in enzyme activity using MUGS substrate incubated for 1 to 2 hrs by spectrofluorometry relative to control | Homo sapiens | 9 | ALA3576868 | single protein format | Scientific Literature | |
3. | ALA3579962 | Binding | Chaperoning efficacy at HexA alpha G269S mutant in ATSD patient fibroblasts assessed as drug level causing maximum increase in enzyme activity using MUGS substrate incubated for 1 to 2 hrs by spectrofluorometry relative to control | Homo sapiens | 7 | ALA3576868 | single protein format | Scientific Literature | |
4. | ALA3579963 | Toxicity | Toxicity against ATSD patient fibroblasts assessed as reduction in beta-galactosidase activity at >400 uM | Homo sapiens | 8 | ALA3576868 | cell-based format | Scientific Literature | |
5. | ALA3579964 | Toxicity | Toxicity against ATSD patient fibroblasts assessed as reduction in beta-galactosidase activity at | Homo sapiens | 4 | ALA3576868 | cell-based format | Scientific Literature | |
6. | ALA663728 | Binding | Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Plasmodium falciparum | Plasmodium falciparum | 48 | ALA1138835 | single protein format | Scientific Literature | |
7. | ALA667200 | Binding | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N DHFR) of Plasmodium falciparum | Plasmodium falciparum | 48 | ALA1138835 | single protein format | Scientific Literature | |
8. | ALA880697 | Binding | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N+I164L DHFR) of Plasmodium falciparum | Plasmodium falciparum | 48 | ALA1138835 | single protein format | Scientific Literature | |
9. | ALA668409 | Binding | Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | ALA1135602 | single protein format | Scientific Literature | |
10. | ALA668410 | Binding | Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | ALA1135602 | single protein format | Scientific Literature | |
11. | ALA668411 | Binding | Inhibition of the wild-type dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | ALA1135602 | single protein format | Scientific Literature | |
12. | ALA668418 | Binding | Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | ALA1135602 | single protein format | Scientific Literature | |
13. | ALA668423 | Binding | Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | ALA1135602 | single protein format | Scientific Literature | |
14. | ALA667612 | Binding | Inhibition of the wild-type dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | ALA1135602 | single protein format | Scientific Literature | |
15. | ALA821377 | Binding | Binding affinity towards wild-type dihydrofolate reductase of Plasmodium falciparum. | Plasmodium falciparum | 48 | ALA1138835 | single protein format | Scientific Literature | |
16. | ALA849932 | Binding | Ratio of Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) to inhibition of wild type dihydrofolate reductase. | Plasmodium falciparum | 40 | ALA1135602 | single protein format | Scientific Literature | |
17. | ALA848232 | Binding | Ratio of Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) to inhibition of wild type dihydrofolate reductase. | Plasmodium falciparum | 40 | ALA1135602 | single protein format | Scientific Literature | |
18. | ALA849104 | Functional | IC50 ratio against Plasmodium falciparum K1CB1/TM4 | Plasmodium falciparum | 43 | ALA1135602 | organism-based format | Scientific Literature | |
19. | ALA847342 | Binding | Ratio of binding affinity for mutant (C59R+S108N+I164L) to that of wild type dihydrofolate reductase | Plasmodium falciparum | 48 | ALA1138835 | single protein format | Scientific Literature | |
20. | ALA847343 | Binding | Ratio of binding affinity for mutant (N51I+C59R+S108N) to that of wild type dihydrofolate reductase | Plasmodium falciparum | 48 | ALA1138835 | single protein format | Scientific Literature |