# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA663728 | B | Binding affinity towards mutant dihydrofolate reductase (C59R+S108N+I164L DHFR) of Plasmodium falciparum | Plasmodium falciparum | 48 | single protein format | Scientific Literature | ||
2. | ALA667200 | B | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N DHFR) of Plasmodium falciparum | Plasmodium falciparum | 48 | single protein format | Scientific Literature | ||
3. | ALA880697 | B | Binding affinity towards mutant dihydrofolate reductase (N51I+C59R+S108N+I164L DHFR) of Plasmodium falciparum | Plasmodium falciparum | 48 | single protein format | Scientific Literature | ||
4. | ALA668409 | B | Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | single protein format | Scientific Literature | ||
5. | ALA668410 | B | Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | single protein format | Scientific Literature | ||
6. | ALA668411 | B | Inhibition of the wild-type dihydrofolate reductase (DHFR) | Plasmodium falciparum | 43 | single protein format | Scientific Literature | ||
7. | ALA668418 | B | Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | single protein format | Scientific Literature | ||
8. | ALA668423 | B | Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | single protein format | Scientific Literature | ||
9. | ALA667612 | B | Inhibition of the wild-type dihydrofolate reductase (DHFR) relative to Pyr. | Plasmodium falciparum | 6 | single protein format | Scientific Literature | ||
10. | ALA762995 | F | Antiplasmodial activity IC50 against Plasmodium falciparum K1CB1 DHFR double-mutant (C59R/S10) | Plasmodium falciparum | 43 | assay format | Scientific Literature | ||
11. | ALA767132 | F | In vitro antiplasmodial activity (IC50) against Plasmodium falciparum wtTM4/8.2 | Plasmodium falciparum | 43 | organism-based format | Scientific Literature | ||
12. | ALA766285 | F | Relative antiplasmodial activity (IC50) compared to Pyr against Plasmodium falciparum K1CB1 DHFR double-mutant (C59R/S108N) | Plasmodium falciparum | 6 | organism-based format | Scientific Literature | ||
13. | ALA766289 | F | In vitro relative antiplasmodial activity (IC50) compared to Pyr against Plasmodium falciparum TM4/8.2 wild-type | Plasmodium falciparum | 6 | organism-based format | Scientific Literature | ||
14. | ALA821377 | B | Binding affinity towards wild-type dihydrofolate reductase of Plasmodium falciparum. | Plasmodium falciparum | 48 | single protein format | Scientific Literature | ||
15. | ALA849932 | B | Ratio of Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR) to inhibition of wild type dihydrofolate reductase. | Plasmodium falciparum | 40 | single protein format | Scientific Literature | ||
16. | ALA848232 | B | Ratio of Inhibition of the S108N mutant of dihydrofolate reductase (DHFR) to inhibition of wild type dihydrofolate reductase. | Plasmodium falciparum | 40 | single protein format | Scientific Literature | ||
17. | ALA849104 | F | IC50 ratio against Plasmodium falciparum K1CB1/TM4 | Plasmodium falciparum | 43 | organism-based format | Scientific Literature | ||
18. | ALA847342 | B | Ratio of binding affinity for mutant (C59R+S108N+I164L) to that of wild type dihydrofolate reductase | Plasmodium falciparum | 48 | single protein format | Scientific Literature | ||
19. | ALA847343 | B | Ratio of binding affinity for mutant (N51I+C59R+S108N) to that of wild type dihydrofolate reductase | Plasmodium falciparum | 48 | single protein format | Scientific Literature | ||
20. | ALA847344 | B | Ratio of binding affinity for mutant (N51I+C59R+S108N+I164L) to that of wild type dihydrofolate reductase | Plasmodium falciparum | 48 | single protein format | Scientific Literature |