# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5040786 | Functional | Antiproliferative activity against human KMS-11 cells assessed as reduction in cell viability incubated for 14 days by LTP assay | Homo sapiens | 2 | ALA5038620 | cell-based format | Scientific Literature | |
2. | ALA5040787 | Binding | Inhibition of SETD2 (unknown origin) preincubated for 30 mins followed by SAM substrate addition measured after 2 hrs by plate reader method | Homo sapiens | 30 | ALA5038620 | single protein format | Scientific Literature | |
3. | ALA5040789 | Binding | Inhibition of SETD2 in human A549 cells assessed as H3K36 trimethyl mark incubated for 3 days by in-cell western assay | Homo sapiens | 17 | ALA5038620 | cell-based format | Scientific Literature | |
4. | ALA5040790 | ADME | Stability in mouse hepatocytes assessed as intrinsic clearance measured upto 60 minutes by LC/MS/MS analysis | Mus musculus | 9 | ALA5038620 | cell-based format | Scientific Literature | |
5. | ALA5040791 | ADME | Stability in human hepatocytes assessed as intrinsic clearance measured upto 120 minutes by LC/MS/MS analysis | Homo sapiens | 9 | ALA5038620 | cell-based format | Scientific Literature | |
6. | ALA5040792 | ADME | Apparent permeability across apical to basal membrane in human Caco-2 cells measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | cell-based format | Scientific Literature | |
7. | ALA5040793 | ADME | Efflux ratio of apparent permeability across basolateral to apical membrane over apical to basolateral membrane in human Caco-2 cells after 2 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | cell-based format | Scientific Literature | |
8. | ALA5040794 | ADME | Inhibition of CYP2C19 in human liver microsomes using (s)-Mephenytoin as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | microsome format | Scientific Literature | |
9. | ALA5040795 | ADME | Inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | microsome format | Scientific Literature | |
10. | ALA5040796 | ADME | Inhibition of CYP2B6 in human liver microsomes using Bupropion as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | microsome format | Scientific Literature | |
11. | ALA5040797 | ADME | Inhibition of CYP2C8 in human liver microsomes using Paclitaxel as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | microsome format | Scientific Literature | |
12. | ALA5040798 | ADME | Inhibition of CYP2C9 in human liver microsomes using Tolbutamide as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | microsome format | Scientific Literature | |
13. | ALA5040799 | ADME | Inhibition of CYP2D6 in human liver microsomes using Dextromethorphan as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | microsome format | Scientific Literature | |
14. | ALA5040800 | ADME | Inhibition of CYP3A4 in human liver microsomes using Midazolam as substrate by LC-MS/MS analysis | Homo sapiens | 1 | ALA5038620 | microsome format | Scientific Literature | |
15. | ALA5040801 | Toxicity | Inhibition of hERG (unknown origin) | Homo sapiens | 1 | ALA5038620 | assay format | Scientific Literature | |
16. | ALA5040802 | ADME | Clearance in CD-1 mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 2 | ALA5038620 | organism-based format | Scientific Literature | |
17. | ALA5040803 | ADME | Volume of distribution in CD-1 mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 2 | ALA5038620 | organism-based format | Scientific Literature | |
18. | ALA5040804 | ADME | Terminal half life in CD-1 mouse at 1 mg/kg, iv by LC-MS/MS analysis | Mus musculus | 2 | ALA5038620 | organism-based format | Scientific Literature | |
19. | ALA5040806 | Functional | Antiproliferative activity against human KMS-34 cells assessed as reduction in cell viability incubated for 14 days by LTP assay | Homo sapiens | 2 | ALA5038620 | cell-based format | Scientific Literature | |
20. | ALA5040807 | ADME | Oral fraction absorbed in CD-1 mouse at 30 mg/kg by LC-MS/MS analysis | Mus musculus | 1 | ALA5038620 | organism-based format | Scientific Literature |