# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5040670 | Binding | Inhibition of bacterial Metallo-beta-lactamase VIM-1 (unknown origin) assessed as substrate hydrolysis using meropenem as substrate by UV-visible spectrometry analysis | Bacteria | 24 | ALA5038617 | assay format | Scientific Literature | |
2. | ALA5040672 | Binding | Inhibition of bacterial Metallo-beta-lactamase VIM-2 (unknown origin) assessed as substrate hydrolysis using meropenem as substrate by UV-visible spectrometry analysis | Bacteria | 21 | ALA5038617 | assay format | Scientific Literature | |
3. | ALA5040674 | Binding | Inhibition of bacterial Metallo-beta-lactamase VIM-4 (unknown origin) assessed as substrate hydrolysis using meropenem as substrate by UV-visible spectrometry analysis | Bacteria | 25 | ALA5038617 | assay format | Scientific Literature | |
4. | ALA5040677 | Binding | Inhibition of bacterial New Delhi metallo-beta-lactamase 1 (unknown origin) assessed as substrate hydrolysis using meropenem as substrate by UV-visible spectrometry analysis | Bacteria | 15 | ALA5038617 | assay format | Scientific Literature | |
5. | ALA5040679 | Binding | Inhibition of bacterial Metallo-beta-lactamase IMP-1 (unknown origin) assessed as substrate hydrolysis using meropenem as substrate by UV-visible spectrometry analysis | Bacteria | 12 | ALA5038617 | assay format | Scientific Literature | |
6. | ALA5040682 | Functional | Synergistic antibacterial activity against Klebsiella pneumonia 7023 clinical isolate strain producing Metallo-beta-lactamase VIM-1 assessed as meropenem MIC in presence of meropenem incubated for 24 hrs by broth microdilution method | Klebsiella pneumoniae | 23 | ALA5038617 | organism-based format | Scientific Literature | |
7. | ALA5040683 | Functional | Synergistic antibacterial activity against Klebsiella pneumonia VA 316 clinical isolate strain producing Metallo-beta-lactamase VIM-4 assessed as meropenem MIC in presence of meropenem incubated for 24 hrs by broth microdilution method | Klebsiella pneumoniae | 23 | ALA5038617 | organism-based format | Scientific Literature | |
8. | ALA5040684 | Functional | Cytotoxicity against human HeLa cells assessed as LDH release measured after 24 hrs by CytoTox96 nonradioactive assay | Homo sapiens | 6 | ALA5038617 | cell-based format | Scientific Literature | |
9. | ALA5040686 | Toxicity | Cytotoxicity against human PBMC cells assessed as cell viability measured after 24 hrs by flowcytometry method | Homo sapiens | 4 | ALA5038617 | cell-based format | Scientific Literature | |
10. | ALA5040687 | Binding | Inhibition of recombinant human Glyoxalase-2 assessed as reduction of substrate level using S-D-lactoylglutathione as substrate by spectrophotometric method | Homo sapiens | 1 | ALA5038617 | single protein format | Scientific Literature |