# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5050624 | B | Inhibition of IDH1 R132H mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-KG as substrate incubated for 60 mins by Kinase-GLO reagent based assay | Homo sapiens | 25 | ALA5046317 | single protein format | Scientific Literature | |
2. | ALA5050625 | F | Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay | Homo sapiens | 25 | ALA5046317 | cell-based format | Scientific Literature | |
3. | ALA5050627 | A | Drug metabolism in rat liver microsomes assessed as GSH-adduct formation at 1 mg/ml and measured after 60 mins in presence of glutathione and NADPH by ion chromatogram analysis relative to control | Rattus norvegicus | 24 | ALA5046317 | microsome format | Scientific Literature | |
4. | ALA5050629 | A | Drug metabolism in human liver microsomes assessed as GSH-adduct formation at 1 mg/ml and measured after 60 mins in presence of glutathione and NADPH by ion chromatogram analysis relative to control | Homo sapiens | 8 | ALA5046317 | microsome format | Scientific Literature | |
5. | ALA5050630 | P | Distribution coefficient, logD of compound at pH 7.4 by HPLC analysis | 1 | ALA5046317 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA5050632 | A | Substrate activity at P-gp (unknown origin) transfected in LLC-PK1 cells expressing human MDR1 gene assessed as efflux ratio of permeability across basolateral to apical membrane at 0.1 uM | Homo sapiens | 20 | ALA5046317 | cell-based format | Scientific Literature | |
7. | ALA5050633 | A | Half life in rat at 0.5 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5046317 | organism-based format | Scientific Literature | |
8. | ALA5050634 | A | Half life in dog at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA5046317 | organism-based format | Scientific Literature | |
9. | ALA5050635 | A | Volume of distribution in rat at 0.5 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5046317 | organism-based format | Scientific Literature | |
10. | ALA5050636 | A | Volume of distribution in dog at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA5046317 | organism-based format | Scientific Literature | |
11. | ALA5050637 | A | Clearance in rat at 0.5 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5046317 | organism-based format | Scientific Literature | |
12. | ALA5050638 | A | Clearance in dog at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA5046317 | organism-based format | Scientific Literature | |
13. | ALA5050639 | A | Oral bioavailability in rat 1 mg/kg measured up to 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA5046317 | organism-based format | Scientific Literature | |
14. | ALA5050640 | A | Oral bioavailability in dog 10 mg/kg measured up to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA5046317 | organism-based format | Scientific Literature | |
15. | ALA5050641 | P | Solubility of the compound at pH 2 | 1 | ALA5046317 | small-molecule physicochemical format | Scientific Literature | ||
16. | ALA5050642 | P | Solubility of the compound at pH 6.5 | 1 | ALA5046317 | small-molecule physicochemical format | Scientific Literature | ||
17. | ALA5050643 | P | Solubility of the compound at pH 7 | 1 | ALA5046317 | small-molecule physicochemical format | Scientific Literature | ||
18. | ALA5050644 | A | Permeability of the compound in pig LLC-PK1 cells expressing MDR1 | Sus scrofa | 1 | ALA5046317 | cell-based format | Scientific Literature | |
19. | ALA5050645 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 16 | ALA5046317 | microsome format | Scientific Literature | |
20. | ALA5050646 | A | Drug metabolism in dog liver microsomes assessed as glutathione-adduct formation measured after 60 mins in presence of NADPH | Canis lupus familiaris | 3 | ALA5046317 | microsome format | Scientific Literature |