| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5032958 | B | Inhibition of human PD-1/PD-L1 interaction assessed as blockade activity incubated for 15 mins by HTRF assay | Homo sapiens | 43 | ALA5032502 | protein complex format | Scientific Literature | |
| 2. | ALA5032959 | B | Binding affinity to human PD-1 assessed as dissociation constant by surface plasmon resonance analysis | Homo sapiens | 1 | ALA5032502 | single protein format | Scientific Literature | |
| 3. | ALA5032960 | B | Binding affinity to human PD-L1 assessed as dissociation constant by surface plasmon resonance analysis | Homo sapiens | 1 | ALA5032502 | single protein format | Scientific Literature | |
| 4. | ALA5032961 | F | Cytotoxicity against human Jurkat cells expressing PD-1/NFAT/Luc assessed as inhibition of cell viability at 0.1 to 10 uM incubated for 24 hrs by CCK8 assay | Homo sapiens | 5 | ALA5032502 | cell-based format | Scientific Literature | |
| 5. | ALA5032962 | F | Cytotoxicity against CHO-K1 cells expressing PD-L1/aAPC assessed as inhibition of cell viability at 0.1 to 10 uM incubated for 24 hrs by MTT assay | Cricetulus griseus | 5 | ALA5032502 | cell-based format | Scientific Literature | |
| 6. | ALA5032963 | F | Cytotoxicity against mouse MC38 cells assessed as inhibition of cell viability at 0.1 to 10 uM incubated for 24 hrs by MTT assay | Mus musculus | 5 | ALA5032502 | cell-based format | Scientific Literature | |
| 7. | ALA5032967 | B | Inhibition of human PD-1/PD-L1 interaction in human Jurkat cells expressing PD-1/NFAT/Luc cocultured with CHO-K1 cells expressing PD-L1/aAPC assessed as Jurkat T-lymphocyte activation measured after 6 hrs by luciferase reporter gene based luminescence assay | Homo sapiens | 3 | ALA5032502 | cell-based format | Scientific Literature | |
| 8. | ALA5032968 | A | Half life in Sprague-Dawley rat at 2 mg/kg, iv measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 9. | ALA5032969 | A | Tmax in Sprague-Dawley rat at 2 mg/kg, iv measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 10. | ALA5032970 | A | Cmax in Sprague-Dawley rat at 2 mg/kg, iv measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 11. | ALA5032971 | A | AUC (0 to t) in Sprague-Dawley rat at 2 mg/kg, iv measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 12. | ALA5032972 | A | Clearance in Sprague-Dawley rat at 2 mg/kg, iv measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 13. | ALA5032973 | A | Half life in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 14. | ALA5032974 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 15. | ALA5032975 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 16. | ALA5032976 | A | AUC (0 to t) in Sprague-Dawley rat at 10 mg/kg, po measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 17. | ALA5032977 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg measured upto 24 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA5032502 | organism-based format | Scientific Literature | |
| 18. | ALA5032997 | B | Inhibition of human ERG | Homo sapiens | 1 | ALA5032502 | single protein format | Scientific Literature | |
| 19. | ALA5033028 | B | Inhibition of human PD-1/PD-L1 interaction in human Jurkat cells expressing PD-1/NFAT/Luc cocultured with CHO-K1 cells expressing PD-L1/aAPC assessed as Jurkat T-lymphocyte activation by measuring relative maximal luminescence value measured after 6 hrs by luciferase reporter gene based luminescence assay | Homo sapiens | 3 | ALA5032502 | cell-based format | Scientific Literature | |
| 20. | ALA5225070 | B | Binding affinity to human PD-1 assessed as dissociation constant by SPR assay | Homo sapiens | 1 | ALA5223128 | single protein format | Scientific Literature |
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