| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5038681 | B | Binding affinity to full length C-terminal Avi/His6-tagged human PCSK9 expressed in Expi293 cells assessed as change in enthalpy by isothermal titration calorimetric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA5038682 | B | Inhibition of tEGF-A[HA] binding to biotinylated human PCSK9 incubated for 2 hrs by ELISA based competitive binding assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA5038683 | B | Binding affinity to full length C-terminal Avi/His6-tagged human PCSK9 expressed in Expi293 cells assessed as equilibrium dissociation constant by surface plasmon resonance assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA5038684 | B | Binding affinity to full length C-terminal Avi/His6-tagged human PCSK9 expressed in Expi293 cells assessed as association rate constant (Kon) by surface plasmon resonance assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA5038685 | B | Binding affinity to full length C-terminal Avi/His6-tagged human PCSK9 expressed in Expi293 cells assessed as dissociation rate constant (Koff) by surface plasmon resonance assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA5038686 | B | Binding affinity to full length C-terminal Avi/His6-tagged human PCSK9 expressed in Expi293 cells assessed as change in entropy by isothermal titration calorimetric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA5038687 | B | Inhibition of PCSK9 in human HepG2 cells assessed as restoration of surface LDLR level at 50 nM incubated for 2 hrs by Western blot analysis (Rvb= 37.5 +/- 13.9%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA5038688 | T | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 10 uM incubated for 48 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA5038690 | B | Inhibition of PCSK9 in human HepG2 cells assessed as restoration of PCSK9-induced reduction in fluorescent LDL uptake at 50 nM incubated for 2 hrs by fluorescence plate reader analysis (Rvb= 46.1 +/- 5.6%) | Homo sapiens | 1 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!